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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
ICMT
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "ICMT" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-16160
CAS No.: 851636-83-4
Research Areas:
Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research .
UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis .
Cat. No.: HY-156500
CAS No.: 1313603-22-3
ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC50=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .
Cat. No.: HY-149711
CAS No.: 68000-92-0
Target:
Research Areas:
Farnesylcysteine (FC) is a competitive inhibitor of ICMT. The fcly mutant has quantitatively low farnesylcysteine (FC) lyase activity and an enhanced response to ABA. Farnesylcysteine induces an ABA hypersensitive phenotype in Arabidopsis thaliana .
Cat. No.: HY-157206
CAS No.: 1313602-77-5
ICMT-IN-55 (compound 31) is an ICMT inhibitor with IC50=90 nM .
UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome .
Cat. No.: HY-149730
CAS No.: 908856-14-4
ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation .
Cat. No.: HY-149707
CAS No.: 1310740-69-2
ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT .
Cat. No.: HY-149705
CAS No.: 1313603-21-2
ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .
Cat. No.: HY-157116
CAS No.: 337486-54-1
ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively .
Cat. No.: HY-149706
CAS No.: 1313603-25-6
ICMT-IN-12 (compound 78) is an inhibitor of ICMT (IC50=0.42 μM) .
Cat. No.: HY-155421
CAS No.: 1313602-94-6
ICMT-IN-11 (compound 48) is an inhibitor of ICMT (IC50=0.031 μM) .
Cat. No.: HY-155422
CAS No.: 1313602-95-7
ICMT-IN-13 (compound 49) is an inhibitor of ICMT (IC50=0.47 μM) .
Cat. No.: HY-155423
CAS No.: 1313602-97-9
ICMT-IN-14 (compound 50) is an inhibitor of ICMT (IC50=0.025 μM) .
Cat. No.: HY-155424
CAS No.: 1313602-98-0
ICMT-IN-15 (compound 51) is an inhibitor of ICMT (IC50=0.032 μM) .
Cat. No.: HY-155425
CAS No.: 1313602-99-1
ICMT-IN-17 (compound 52) is an inhibitor of ICMT (IC50=0.38 μM) .
Cat. No.: HY-155426
CAS No.: 1313603-00-7
ICMT-IN-19 (compound 53) is an inhibitor of ICMT (IC50=0.026 μM) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
