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Results for "

KDM1A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Histone Demethylase (20) Notch (2) Reference Standards (2) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (2)
By Research Areas:	Cancer (15) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12782T

Iadademstat dihydrochloride 5+ Cited Publications ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride	Histone Demethylase	Cancer
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.

HY-18632

GSK2879552 Maximum Cited Publications 19 Publications Verification	Histone Demethylase	Cancer
GSK2879552 an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/ KDM1A), with potential antineoplastic activity ^[1] .

HY-109117

Iadademstat 5+ Cited Publications ORY-1001	Histone Demethylase Apoptosis	Cancer
Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research ^[1].

HY-18632A

GSK2879552 dihydrochloride Maximum Cited Publications 19 Publications Verification	Histone Demethylase	Cancer
GSK2879552 dihydrochloride an orally active, selective and irreversible inhibitor of lysine specific demethylase 1 (LSD1/KDM1A), with potential antineoplastic activity ^[1] .

HY-103713

Seclidemstat 10+ Cited Publications SP-2577	Histone Demethylase	Cancer
Seclidemstat is a potent noncompetitive and reversible **KDM1A (LSD1) inhibitor (K_i=31 nM, IC₅₀**=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma ^[1] .

HY-19612A

DDP-38003 dihydrochloride 1 Publications Verification	Histone Demethylase	Cancer
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM ^[1].

HY-138830

TAK-418 2 Publications Verification	Histone Demethylase	Neurological Disease
TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC₅₀ of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models ^[1] .

HY-103713A

Seclidemstat mesylate 10+ Cited Publications SP-2577 mesylate	Histone Demethylase	Cancer
Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible **KDM1A (LSD1) inhibitor (K_i=31 nM, IC₅₀**=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma ^[1] .

HY-RS07205

KDM1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KDM1A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM1A Human Pre-designed siRNA Set A KDM1A Human Pre-designed siRNA Set A

HY-RS07206

Kdm1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm1a Mouse Pre-designed siRNA Set A Kdm1a Mouse Pre-designed siRNA Set A

HY-RS07207

Kdm1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm1a Rat Pre-designed siRNA Set A Kdm1a Rat Pre-designed siRNA Set A

HY-19612B

DDP-38003 trihydrochloride	Histone Demethylase	Cancer
DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC₅₀ of 84 nM.

HY-19612

DDP-38003	Histone Demethylase	Cancer
DDP-38003 (Compound 15) is an orally active *KDM1A/LSD1* inhibitor with an IC₅₀ value of 84 nM. DDP-38003 exhibits anticancer activity against promyelocytic leukemia ^[1].

HY-143238

FY-56	Histone Demethylase	Cancer
FY-56 is a highly potent and selective *LSD1/KDM1A* inhibitor (IC₅₀=42 nM) and exhibits high selectivity over MAO-A/B. FY-56 induces differentiation of MOLM-13 and MV4-11 cell and has the potential for AML research ^[1].

HY-123577

TPC-144	Histone Demethylase Apoptosis	Cancer
TPC-144 is a *LSD1/KDM1A* inhibitor. TPC-144 inhibits LSD1, and leads to a decrease in the protein level of DNMT1, causing low methylation of the LINE-1 element. TPC-144 can also produce a synergistic effect with Decitabine (HY-A0004) (a DNMT inhibitor), jointly promoting DNA demethylation and thereby inducing differentiation and apoptosis of leukemia cells. TPC-144 has also demonstrated anti-tumor efficacy in acute myeloid leukemia (AML) models. TPC-144 can be used for the study of AML ^[1] .

HY-112304

NCD38 TFA	Histone Demethylase	Others
NCD38 TFA is a *LSD1*-selective inhibitor ^[1] .

HY-112304A

(1R,2S)-NCD38 TFA	Histone Demethylase	Others
(1R,2S)-NCD38 TFA is an enantiomer of NCD38 TFA. NCD38 TFA is a *LSD1*-selective inhibitor ^[1] .

HY-186116

LSD1-IN-49	Histone Demethylase	Others
LSD1-IN-49 is a Lysine-specific demethylase 1 (LSD1/KDM1A) inhibitor with a human IC₅₀ of 29 nM. LSD1-IN-49 irreversibly inhibits LSD1 enzyme activity by forming an adduct with the flavin adenine dinucleotide (FAD) cofactor of LSD1. LSD1-IN-49 can be used as a lead compound for the development of LSD1-targeted PET imaging agents for the brain ^[1].

HY-186116A

LSD1-IN-49 hydrochloride	Histone Demethylase	Neurological Disease
LSD1-IN-49 hydrochloride (Compound (±) 1) is an irreversible *LSD1*/KDM1A inhibitor with an IC₅₀ of 29 nM against hLSD1. LSD1-IN-49 hydrochloride irreversibly inhibits the enzymatic activity of *LSD1* by forming an adduct with flavin adenine dinucleotide (FAD) in the binding pocket of *LSD1. LSD1-IN-49* hydrochloride is applicable to research related to schizophrenia, autism spectrum disorder and Huntington's disease ^[1].

HY-103713AR

Seclidemstat mesylate (Standard) SP-2577 mesylate (Standard)	Reference Standards Histone Demethylase	Cancer
Seclidemstat mesylate (Standard) is the analytical standard of Seclidemstat mesylate (HY-103713A). This product is intended for research and analytical applications. Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC₅₀=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma ^[1] .

HY-103713R

Seclidemstat (Standard) SP-2577 (Standard)	Reference Standards Histone Demethylase	Cancer
Seclidemstat (Standard) is the analytical standard of Seclidemstat (HY-103713). This product is intended for research and analytical applications. Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC₅₀=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma ^[1] .

HY-183067

TAS1440	Histone Demethylase TGF-beta/Smad Notch	Cancer
TAS1440 is an orally active *LSD1/KDM1A* inhibitor with a human IC₅₀ of 4.8 nM. TAS1440 non-covalently binds to the histone H₃-binding pocket of LSD1, inhibiting demethylase activity and disrupting repressive complexes with *INSM1* and SMAD2. TAS1440 activates tumor-suppressive TGF-β and NOTCH signaling pathways via transcriptional reprogramming. TAS1440 can be used for the research of small cell lung cancer, specifically the SCLC-A subtype ^[1].

HY-183067A

TAS1440 benzoate	Histone Demethylase TGF-beta/Smad Notch	Cancer
TAS1440 benzoate is an orally active *LSD1/KDM1A* inhibitor with a human IC₅₀ of 4.8 nM. TAS1440 benzoate non-covalently binds to the histone H3-binding pocket of LSD1, inhibiting demethylase activity and disrupting repressive complexes with *INSM1* and SMAD2. TAS1440 benzoate activates tumor-suppressive TGF-β and NOTCH signaling pathways via transcriptional reprogramming. TAS1440 benzoate can be used for the research of small cell lung cancer, specifically the SCLC-A subtype ^[1].

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75551

	LSD1 Protein, Human (sf9, His-GST) 1 Publications Verification Lysine-specific histone demethylase 1A; KDM1A; AOF2; KDM1; KIAA0601; LSD1	Human	Sf9 insect cells
	The LSD1 protein is a histone demethylase that modifies histone H3 by demethylating “Lys-4” (H3K4me) and “Lys-9” (H3K9me).It acts as a coactivator or corepressor, oxidizing substrates via FAD to generate imines that are subsequently hydrolyzed.LSD1 Protein, Human (sf9, His-GST) is the recombinant human-derived LSD1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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Host:	Mouse (4)
Reactivity:	Human (4) Bovine (1) Mouse (3) Monkey (3) Dog (1) Pig (1)
Application:	IHC-P (1) ICC/IF (2) IP (1) WB (4)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

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HY-P85442

	KDM1/LSD1 Antibody (YA5134) KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2	WB, IHC-P, ICC/IF	Human, Mouse, Bovine, Dog, Pig
	KDM1/LSD1 Antibody (YA5134) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM1/LSD1.

HY-P80731

	KDM1/LSD1 Antibody (YA718) KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2	WB	Human, Mouse, Monkey
	KDM1/LSD1 Antibody (YA718) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KDM1/LSD1.

HY-P80731A

	KDM1/LSD1 Antibody (YA718)(PBS only) KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2	WB	Human, Mouse, Monkey
	KDM1/LSD1 Antibody (YA718) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KDM1/LSD1.

HY-P85484

	KDM1/LSD1 Antibody (YA5176) Amine oxidase; flavin containing; domain 2; AOF2; BHC110; BRAF35 HDAC complex protein BHC110; BRAF35-HDAC complex protein BHC110; FAD binding protein BRAF35 HDAC complex, 110 kDa subunit; Flavin-containing amine oxidase domain-containing protein 2; KDM 1; KDM1; KDM1A; KDM1A_HUMAN; LSD 1; LSD1; Lysine; K; specific demethylase 1; Lysine; K; specific demethylase 1A; Lysine specific histone demethylase 1; Lysine specific histone demethylase 1A; Lysine-specific histone demethylase 1A.	WB, ICC/IF, IP	Human, Monkey
	KDM1/LSD1 Antibody (YA5176) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KDM1/LSD1.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

KDM1A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KDM1A Human Pre-designed siRNA Set A contains three designed siRNAs for KDM1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm1a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kdm1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm1a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kdm1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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