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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
LWY713
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "LWY713" in MCE Product Catalog:
Cat. No.: HY-157213
LWY713 is a FLT3 PROTAC degrader with a DC50 of 0.64 nM. LWY713 selectively induces FLT3 degradation in a cereblon- and proteasome-dependent manner. LWY713 induces G0/G1 cell cycle arrest and triggers apoptosis. LWY713 upregulates PARP and cleaved caspase 3, and inhibits the phosphorylation of FLT3, STAT5, AKT and Erk. LWY713 exhibits antitumor activity in xenograft mouse models. LWY713 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-W039233
CAS No.: 2359705-88-5
Target:
Research Areas:
Lenalidomide-F is a CRBN ligand. Lenalidomide-F can be conjugated with the FLT3 ligand Gilteritinib (HY-12432) via the linker Glycolic acid (HY-W015967) to synthesize the FLT3 PROTAC degrader LWY713 (HY-157213). Lenalidomide-F is applicable to the research of acute myeloid leukemia .
Cat. No.: HY-169373
CAS No.: 2229976-15-0
Research Areas:
Lenalidomide-Glycolic acid is a E3 Ligase Ligand-Linker Conjugate for PROTAC-class FLT3 degrader LWY713 (HY-157213) .
Cat. No.: HY-169374
CAS No.: 1373410-40-2
Research Areas:
Naproxen Gilteritinib is the active reference substance of Gilteritinib (HY-12432). Gilteritinib is the target protein ligand of PROTAC degrader LWY713 (HY-157213) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
