Naproxen Gilteritinib

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	0.31 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
BaF3	IC₅₀	0.43 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y double mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y double mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
BaF3	IC₅₀	0.55 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
BaF3	IC₅₀	2.17 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835F mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835F mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
BaF3	IC₅₀	29.38 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L double mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L double mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
BaF3	IC₅₀	563.85 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
BaF3	IC₅₀	6.03 nM Compound: 2	Antiproliferative activity against mouse BaF3 cells expressing FLT3-F691L mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against mouse BaF3 cells expressing FLT3-F691L mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
HeLa	IC₅₀	4769 nM Compound: 2	Antiproliferative activity against human Hela cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human Hela cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
Kasumi 1	IC₅₀	291.03 nM Compound: 2	Antiproliferative activity against human Kasumi-1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human Kasumi-1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
MCF7	IC₅₀	634.03 nM Compound: 2	Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
MM1.S	IC₅₀	399.65 nM Compound: 2	Antiproliferative activity against human MM.1S cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human MM.1S cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 35138851]
MV4-11	IC₅₀	6.54 nM Compound: 2	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 35138851]
PBMC	IC₅₀	9854.67 nM Compound: 2	Antiproliferative activity against human PBMC cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human PBMC cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
WI-38	IC₅₀	1294 nM Compound: 2	Antiproliferative activity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]
Z-138	IC₅₀	630.4 nM Compound: 2	Antiproliferative activity against human Z138 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human Z138 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 35138851]

Cell Line

Type

Value

Description

References

BaF3

IC₅₀

0.31 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835V mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

BaF3

IC₅₀

0.43 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-D835Y double mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

BaF3

IC₅₀

0.55 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

BaF3

IC₅₀

2.17 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing FLT3-D835F mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

BaF3

IC₅₀

29.38 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing FLT3-ITD-F691L double mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

BaF3

IC₅₀

563.85 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

BaF3

IC₅₀

6.03 nM

Compound: 2

Antiproliferative activity against mouse BaF3 cells expressing FLT3-F691L mutant assessed as inhibition of cell proliferation measured after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

HeLa

IC₅₀

4769 nM

Compound: 2

Antiproliferative activity against human Hela cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

Kasumi 1

IC₅₀

291.03 nM

Compound: 2

Antiproliferative activity against human Kasumi-1 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

MCF7

IC₅₀

634.03 nM

Compound: 2

Antiproliferative activity against human MCF-7 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

MM1.S

IC₅₀

399.65 nM

Compound: 2

Antiproliferative activity against human MM.1S cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay

[PMID: 35138851]

MV4-11

IC₅₀

6.54 nM

Compound: 2

Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay

[PMID: 35138851]

PBMC

IC₅₀

9854.67 nM

Compound: 2

Antiproliferative activity against human PBMC cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

WI-38

IC₅₀

1294 nM

Compound: 2

Antiproliferative activity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

Z-138

IC₅₀

630.4 nM

Compound: 2

Antiproliferative activity against human Z138 cells assessed as reduction in cell viability after 72 hrs by celltiter-glo luminescent cell viability assay

[PMID: 35138851]

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Naproxen Gilteritinib

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