2. Search Result
Search Result
Results for "

MCH-1R

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

3

Peptides

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1205A
    MCH(human, mouse, rat) TFA
    1 Publications Verification

    Melanin-concentrating hormone(human, mouse, rat) TFA

    		 MCHR1 (GPR24) Neurological Disease Metabolic Disease
    MCH (human, mouse, rat) TFA is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) TFA also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) TFA acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) TFA can be used in studies related to obesity, sleep disorders, and other associated conditions [1] .
    MCH(human, mouse, rat) TFA
  • HY-107624
    ATC0175
    1 Publications Verification

    		 MCHR1 (GPR24) Neurological Disease
    ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders [1].
    ATC0175
  • HY-P1205
    MCH(human, mouse, rat)
    1 Publications Verification

    Melanin-concentrating hormone(human, mouse, rat)

    		 MCHR1 (GPR24) Neurological Disease Metabolic Disease
    MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions [1] .
    MCH(human, mouse, rat)
  • HY-P3155
    Ac-hMCH(6-16)-NH2

    		MCHR1 (GPR24) Neurological Disease Metabolic Disease
    Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R [1].
    Ac-hMCH(6-16)-NH2
  • HY-107623
    TC-MCH 7c

    		MCHR1 (GPR24) Metabolic Disease
    TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH1R antagonist with an IC50 of 5.6 nM for hMCH1R [1]. TC-MCH 7c has Kis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively .
    TC-MCH 7c
  • HY-111072
    ADS103317

    		Drug Derivative EGFR MCHR1 (GPR24) Cancer
    ADS103317 is an analog of Afatinib (HY-10261). ADS103317 weakly inhibits MCH-1R. Afatinib is an EGFR inhibitor. ADS103317 can be used in research related to non-small cell lung cancer [1] .
    ADS103317
  • HY-RS08225
    MCHR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MCHR1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCHR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MCHR1 Human Pre-designed siRNA Set A
    MCHR1 Human Pre-designed siRNA Set A
  • HY-RS08226
    Mchr1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Mchr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mchr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mchr1 Mouse Pre-designed siRNA Set A
    Mchr1 Mouse Pre-designed siRNA Set A
  • HY-RS08227
    Mchr1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Mchr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mchr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mchr1 Rat Pre-designed siRNA Set A
    Mchr1 Rat Pre-designed siRNA Set A
  • HY-107624R
    ATC0175 (Standard)

    		Reference Standards MCHR1 (GPR24) Neurological Disease
    ATC0175 (Standard) is the analytical standard of ATC0175 (HY-107624). This product is intended for research and analytical applications. ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders [1].
    ATC0175 (Standard)

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: