128315-56-0
Chemical Structure
MCH(human, mouse, rat)
Synonym(s): Melanin-concentrating hormone(human, mouse, rat)
- CAS No.: 128315-56-0
- Formula:C105H160N30O26S4
- Molecular Weight:2386.84
SMILES: O=C([C@H]1NC(C2([H])N(CCC2)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CSSC1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)CCSC)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC4=CC=C(C=C4)O)=O)CCCNC(N)=N)=O)=O)N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)CC5=CNC6=CC=CC=C56
Biological Activity: MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions[1][2][3][4].
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MCH(human, mouse, rat) | 99.40% | MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions. | ||||||||||||||||||||
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References
- [1]. Diniz GB, et al. The Melanin-Concentrating Hormone (MCH) System: A Tale of Two Peptides. Front Neurosci. 2019;13:1280. Published 2019 Nov 26. [Content Brief]
- [2]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. [Content Brief]
- [3]. Griffond B, et al. MCH and feeding behavior-interaction with peptidic network. Peptides. 2009;30(11):2045-2051. [Content Brief]
- [4]. Gao XB, et al. Electrophysiological effects of MCH on neurons in the hypothalamus. Peptides. 2009;30(11):2025-2030. [Content Brief]
