864756-35-4
864756-35-4
Chemical Structure
TC-MCH 7c
- CAS No.: 864756-35-4
- Formula:C24H25FN2O3
- Molecular Weight:408.47
IUPAC Name: 4-((4-fluorobenzyl)oxy)-1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyridin-2(1H)-one
InChIKey: ANCFKYJMXNMYNZ-UHFFFAOYSA-N
SMILES: O=C1N(C=CC(OCC2=CC=C(F)C=C2)=C1)C3=CC=C(OCCN4CCCC4)C=C3
Biological Activity: TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH1R antagonist with an IC50 of 5.6 nM for hMCH1R[1]. TC-MCH 7c has Kis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TC-MCH 7c | 99.79% | TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH1R antagonist with an IC50 of 5.6 nM for hMCH1R. TC-MCH 7c has Kis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively. | ||||||||||||||||||||
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References
- [1]. Ito M, et al. Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur J Pharmacol. 2009 Dec 10;624(1-3):77-83. [Content Brief]
- [2]. Haga Y, et al. Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg Med Chem. 2011 Jan 15;19(2):883-93. [Content Brief]
Keywords
