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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Metiamide
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Metiamide" in MCE Product Catalog:
1
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Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.
1
Cat. No.: HY-P4070
CAS No.: 1188379-43-2
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Cat. No.: HY-P11293
CAS No.: 1309855-53-5
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Cat. No.: HY-P4757
CAS No.: 108081-77-2
Cat. No.: HY-155297
CAS No.: 55248-23-2
Synonyms: FLA-136
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Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation .
Cat. No.: HY-P1321
CAS No.: 158859-98-4
Synonyms: 1229U91; GW1229
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Cat. No.: HY-15540R
CAS No.: 34839-70-8
Synonyms: SK&F 92058 (Standard)
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Metiamide (Standard) is the analytical standard of Metiamide. This product is intended for research and analytical applications. Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.
Cat. No.: HY-P1321A
Synonyms: 1229U91 TFA; GW1229 TFA
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Cat. No.: HY-P11480
CAS No.: 3105660-96-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
