1030384-98-5
Chemical Structure
CTCE-9908
- CAS No.: 1030384-98-5
- Formula:C86H147N27O23
- Molecular Weight:1927.25
IUPAC Name: (2S,2'S)-N,N'-((4S,7S,10S,13S,16S,19S,22S,29S,32S,35S,38S,41S,44S)-22-carbamoyl-19,29-bis(3-guanidinopropyl)-16,32-bis(4-hydroxybenzyl)-7,13,35,41-tetrakis(hydroxymethyl)-10,38-diisobutyl-4,44-diisopropyl-2,5,8,11,14,17,20,28,31,34,37,40,43,46-tetradecaoxo-3,6,9,12,15,18,21,27,30,33,36,39,42,45-tetradecaazaheptatetracontane-1,47-diyl)bis(2,6-diaminohexanamide)
InChIKey: VUYRSKROGTWHDC-HZGLMRDYSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](C(C)C)NC(CNC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCCNC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](C(C)C)NC(CNC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O
Biological Activity: CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CTCE-9908 | 99.54% | CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells. | ||||||||||||||||||||
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References
- [1]. Joseph Kwong, et al. An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol Cancer Ther. 2009 Jul;8(7):1893-905. [Content Brief]
- [2]. Saima Hassan, et al. CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer. 2011 Jul 1;129(1):225-32. [Content Brief]
