158859-98-4
Chemical Structure
GR231118
Synonym(s): 1229U91; GW1229
- CAS No.: 158859-98-4
- Formula:C110H170N34O24
- Molecular Weight:2352.74
IUPAC Name: (6S,12S,14aS,20S,26S)-6,20-bis((2S,3S)-2-amino-3-methylpentanamido)-N12,N26-bis((6S,9S,12S,15S)-1-amino-6-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamoyl)-12-(3-guanidinopropyl)-16-(4-hydroxyphenyl)-1-imino-9-isobutyl-8,11,14-trioxo-2,7,10,13
InChIKey: RJRBRCCJETZJLT-MUQWFOTFSA-N
SMILES: O=C1N2[C@](CCC2)([H])C(N[C@@H](CNC(CC[C@@H](C(N3C(CCC3)([H])C(N[C@@H](CNC(CC[C@@H]1NC([C@@H](N)[C@@H](C)CC)=O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)CC7=CC=C(C=C7)O)=O)=O
Biological Activity: GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].
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GR231118 | GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8). | |||||||||||||||||||||
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Keywords
