Search Result
Results for "
Mouse IgG1 kappa, Isotype Control
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P99137
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IFNAR
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Inflammation/Immunology
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Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3) .
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- HY-P991446
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Influenza Virus
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Infection
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MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
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- HY-P991481
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CCR
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Inflammation/Immunology
Cancer
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S-531011 is a human IgG1 monoclonal antibody (mAb) targeting CCR8. S-531011 reduces tumor-infiltrating CCR8+ Tregs and has anti-tumor activity in CT26.WT and EMT6 tumor-bearing mouse tumor models. S-531011 can be used in the study of cancer immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990870
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CD19
IFNAR
Interleukin Related
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Inflammation/Immunology
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Anti-CD19 Antibody (4G7) is an anti-human CD19 IgG1 monoclonal antibody. Anti-CD19 Antibody (4G7) reduces the killing effect of CAR T cells on Raji cells. Anti-CD19 Antibody (4G7) can be used for research on immunology. Anti-CD19 Antibody (4G7) is often used in flow cytometry. The recommend isotype control of Anti-CD19 Antibody (4G7): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991278
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Interleukin Related
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Inflammation/Immunology
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ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations .
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- HY-P990953
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Gen1047
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CD3
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Cancer
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Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of B7H4-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of B7H4-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer) .
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- HY-P990572
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DCBY02
1 Publications Verification
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Transmembrane Glycoprotein
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Inflammation/Immunology
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DCBY02 is a monoclonal antibody targeting CD93 expressed in CHO cells. DCBY02 has a heavy chain of the mlgG type and a light chain of the mkappa type, with a predicted molecular weight (MW) of 150 kDa. The isotype control for DCBY02 can be referenced as Mouse IgG1 kappa, Isotype Control.
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- HY-P990797
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IFNAR
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Infection
Inflammation/Immunology
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Anti-Mouse IFN gamma Antibody (R4-6A2) is an anti-mouse IFN gamma IgG1 monoclonal antibody. Anti-Mouse IFN gamma Antibody (R4-6A2) can increase the total serum IgG level. Anti-Mouse IFN gamma Antibody (R4-6A2) can be used for researches on immunology and infection conditions such as nymphs infection. The recommend isotype control of Anti-Mouse IFN gamma Antibody (R4-6A2): Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P990818
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Fc Receptor (FcR)
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Inflammation/Immunology
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Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can effectively bind to FcRn and competitively inhibit the binding of IgG to FcRn. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can reduce the total serum IgG level. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can be used for researches on autoimmune conditions such as experimental autoimmune myasthenia gravis (EAMG). The recommend isotype control of Anti-Rat FcRn heavy chain heterodimers Antibody (1G3): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991447
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VISTA
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Cancer
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Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991842
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CD3
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Inflammation/Immunology
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Anti-CD3 Antibody (UCHT-1) reacts with human CD3ε. Anti-CD3 Antibody (UCHT-1) can be used for the study of graft-versus-host disease (GVHD). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991792
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Phosphatase
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Cancer
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Anti-Rat pan-CD45 Antibody (OX1) reacts with a common epitope present on all isotypes of rat CD45. CD45 is largely expressed in the lymphoid system, but it is also found in all hematopoietic cells except erythrocytes and platelets. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P990800
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Interleukin Related
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Inflammation/Immunology
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Anti-Mouse IL-4 Antibody (BVD6-24G2) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (BVD6-24G2) can inhibit IL-4 signaling and promote Treg differentiation. Anti-Mouse IL-4 Antibody (BVD6-24G2) can be used for research on immunology. The recommend isotype control of Anti-Mouse IL-4 Antibody (BVD6-24G2): Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991750
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MHC
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Inflammation/Immunology
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Anti-pan MHC Class II (HLA II) Antibody (IVA12) recognizes human HLA-II (HLA-DR, HLA-DP, and HLA-DQ). Anti-pan MHC Class II (HLA II) Antibody (IVA12) blocks MHC-II in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P990400
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Discoidin Domain Receptor
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Inflammation/Immunology
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Anti-DDR1/CD167a Antibody is a CHO-expressed antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a mouse IgG1 type heavy chain and a mouse κ type light chain, with a predicted molecular weight (MW) of 143.32 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P990241
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TNF Receptor
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Inflammation/Immunology
Cancer
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Anti-Mouse GITR (D265A) Antibody (DTA-1) is an anti-mouse GITR IgG1 monoclonal antibody. Anti-Mouse GITR (D265A) Antibody (DTA-1) is a chimeric antibody of the original DTA-1 antibody (HY-P990124). Anti-Mouse GITR (D265A) Antibody (DTA-1) contains the D265A mutation region. Anti-Mouse GITR (D265A) Antibody (DTA-1) can be used for research on cancer and allergic conditions. The recommed isotype control of Anti-Mouse GITR (D265A) Antibody (DTA-1) is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991310
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LT3015; LT-3000
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LPL Receptor
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Neurological Disease
Cancer
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Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P990869
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CD1
IFNAR
Interleukin Related
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Inflammation/Immunology
Cancer
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Anti-CD1a Antibody (OKT-6) is an anti-human CD1a IgG1 monoclonal antibody. Anti-CD1a Antibody (OKT-6) blocks T cell activation by blocking CD1a function. Anti-CD1a Antibody (OKT-6) can reduce the production of IFN-γ. Anti-CD1a Antibody (OKT-6) can be used for researches on cancer and inflammation such as leukemia. The recommend isotype control of Anti-CD1a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P990867
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Insulin Receptor
Akt
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Cancer
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Anti-CD220/Insulin Receptor Antibody (IR 83-22) is an anti-human CD220/Insulin Receptor IgG1 monoclonal antibody. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can block Akt overactivation caused by Trip13 deficiency. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can be used for research on cancer such as hepatocellular carcinoma (HCC). Anti-CD220/Insulin Receptor Antibody (IR 83-22) often used in western blotting. The recommend isotype control of Anti-CD220/Insulin Receptor Antibody (IR 83-22): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991425
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Transmembrane Glycoprotein
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Cancer
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AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acute myeloid leukemia (AML) cells. AT-1413 has antitumor activity in AML mouse models. AT-1413 can be used in Acute myeloid leukaemia, Breast cancer, Malignant melanoma and Myelodysplastic syndromes research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P991468
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Interleukin Related
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Cancer
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IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC50 values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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- HY-P992203
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CD47
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Others
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Anti-CD172a Antibody (3F9) is a humanized IgG1 monoclonal antibody targeting SIRPα/CD172a. The recommended isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991992
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Thrombin
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Cardiovascular Disease
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Anti-Factor X Antibody is an anti-Factor X antibody. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991890
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CD1
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Inflammation/Immunology
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Anti-CD1a Antibody is an antibody against human CD1a. Recommend Isotype Controls:?Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991784
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EGFR
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Cancer
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Anti-Mouse/Human EGFR (domain III) Antibody (EMab-88) reacts with domain III of the mouse and human EGFR. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P992196
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CD28
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Inflammation/Immunology
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Anti-Canine CD28 Antibody (1C6) is a mouse-derived monoclonal antibody that targets canine CD28, which isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P992070
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C-type Lectin-like Receptors (CTLRs)
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Others
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Anti-Human/Mouse NKG2D Antibody (ADI-27740) is an antibody targeting human/mouse NKG2D. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991822
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MHC
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Inflammation/Immunology
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Anti-Mouse H-2b Antibody (B8-24-3) reacts with the mouse H-2b. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992271
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GDNF Receptor
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Inflammation/Immunology
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Anti-Neublastin Antibody is a monoclonal antibody targeting neublastin. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Neublastin Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991753
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CXCR
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Inflammation/Immunology
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Anti-Mouse CCL5 Antibody (R6G9) reacts with mouse CCL5 that can neutralize CCL5 both in vitro and in vivo. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991834
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Integrin
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Cardiovascular Disease
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Anti-Mouse CD41 Antibody (S-R690) reacts with mouse CD41. CD41 is a crucial protein involved in platelet aggregation and hemostasis. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).
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- HY-P991825
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Integrin
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Inflammation/Immunology
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Anti-Mouse CD18 Antibody (C71/16) reacts with an epitope on mouse CD18. CD18 is the Integrin β2 chain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991781
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CXCR
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Inflammation/Immunology
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Anti-Mouse CXCR6 Antibody (Cx6Mab-1) reacts with the N-terminal extracellular ligand-binding domain of mouse CXCR6. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991833
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CD28
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Inflammation/Immunology
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Anti-Mouse BTLA/CD272 Antibody (PK18.6) reacts with mouse B- and T-lymphocyte attenuator (BTLA). BTLA is an Ig superfamily member. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991757
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PSMA
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Cancer
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Anti-Human/Mouse/Rat/Canine/Swine PSMA Antibody (3F11) reacts with prostate-specific membrane antigen (PSMA) from human, mouse, rat, canine and swine species. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991765
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VISTA
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Inflammation/Immunology
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Anti-VISTA Antibody (GG8) reacts with human VISTA. Endogenous VISTA has inhibitory effects both as a ligand on APCs and as a receptor on T cells. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992069
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C-type Lectin-like Receptors (CTLRs)
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Others
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Anti-Human/Mouse NKG2D Antibody (ADI-27724) is an antibody targeting human/mouse NKG2D. The isotype control for Anti-Human/Mouse NKG2D Antibody (ADI-27724) can be referenced as Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991745
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CCR
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Inflammation/Immunology
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Anti-Mouse CCR2 Antibody (C2Mab-6) is raised against and binds to the N-terminal sequence of CCR2. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P992013
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CXCR
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Others
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Anti-CXCR3 Antibody (5H7) is a mouse monoclonal antibody produced using CXCR3 as the antigen. The recommended isotype control is human IgG1 kappa (HY-P99001).
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- HY-P992277
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Transmembrane Glycoprotein
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Inflammation/Immunology
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Anti-NKp46 Antibody is a monoclonal antibody targeting NKp46. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NKp46 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P992240
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Interleukin Related
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Inflammation/Immunology
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Anti-IL-19 Antibody is a monoclonal antibody that targets IL-19. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-19 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991783
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EGFR
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Cancer
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Anti-Mouse EGFR (domain I) Antibody (EMab-300) reacts with domain I of the mouse EGFR. Anti-Mouse EGFR (domain I) Antibody (EMab-300) applies to the detection of mouse EGFR using flow cytometry. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991759
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Transmembrane Glycoprotein
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Inflammation/Immunology
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Anti-Rat CD86 Antibody (OX-48) recognizes CD86, thereby blocking the binding of CD86 to CD28, and thus inhibiting T cell proliferation. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992207
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SHP1
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Inflammation/Immunology
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Anti-CD300A Antibody is a monoclonal antibody targeting CD300A. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD300A Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991793
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Phosphatase
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Inflammation/Immunology
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Anti-Rat CD45RC Antibody (OX22) reacts with rat CD45RC. CD45RC molecule is involved in lymphocyte signaling and is associated with inflammatory responses. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991840
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Transmembrane Glycoprotein
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Inflammation/Immunology
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Anti-CD68 Antibody (KP1) is a anti-CD68 monoclonal antibody (mAb). CD68 is present in various cell types, including monocytes/macrophages and fibroblasts. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992068
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C-type Lectin-like Receptors (CTLRs)
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Others
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Anti-Human/Monkey NKG2D Antibody (ON72) is an antibody targeting human/monkey NKG2D. The isotype control for Anti-Human/Monkey NKG2D Antibody (ON72) can be referenced as Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991853
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Prostaglandin Receptor
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Inflammation/Immunology
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Anti-MSMP/PSMP Antibody (3D5) reacts with human MSMP (Prostate-associated microsemino protein). Anti-MSMP/PSMP Antibody (3D5) significantly ameliorates fibrosis in mice. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991815
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Transmembrane Glycoprotein
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Inflammation/Immunology
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Anti-Mouse CD90.1 Antibody (OX-7) reacts with the mouse and rat CD90.1. CD90 is present on a variety of cell types in murine and rat, including lymphatic vessels, T cells, neurons and fibroblasts. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992273
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Trk Receptor
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Inflammation/Immunology
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Anti-NGF2 Antibody is a monoclonal antibody targeting NGF2/NT-3. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NGF2 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991752
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CXCR
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Cancer
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Anti-Mouse CXCL16 Antibody (12-81) reacts with the extracellular domain of CXCL16. Anti-Mouse CXCL16 Antibody (12-81) can neutralize CXCL16/SR-PSOX both in vitro and in vivo. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991780
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EGFR
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Cancer
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Anti-Mouse HER2 (domain I) Antibody (H2Mab-304) reacts with domain I of mouse HER2. HER2 is a 185 kDa transmembrane receptor tyrosine kinase that is part of the EGFR family. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).
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- HY-P991818
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C-type Lectin-like Receptors (CTLRs)
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Inflammation/Immunology
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Anti-Mouse CD370 Antibody (1F6) reacts with the mouse CD370 (also known as CLEC9A or DNGR1). CD370 is a type II membrane protein with a single extracellular C-type lectin domain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991847
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PD-1/PD-L1
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Cancer
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Anti-PD-L2 Antibody (3.2) recognizes an epitope on mouse and human PD-L2. PD-L2 is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992289
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PD-1/PD-L1
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Inflammation/Immunology
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Anti-PD-L2 Antibody is a monoclonal antibody targeting PD-L2/CD273. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PD-L2 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
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- HY-P991838
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Transferrin Receptor
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Cancer
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Anti-CD71 Antibody (T56/14) reacts with human CD71. Anti-CD71 Antibody (T56/14) is a non-neutralizing antibody that does not inhibit the binding of transferrin. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991755
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CD47
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Neurological Disease
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Anti-Rat CD47 Antibody (OX-101) reacts with CD47. Anti-Rat CD47 Antibody (OX-101) accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991794
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L-Selectin
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Cancer
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Anti-Rat L-selectin Antibody (OX-85) reacts with rat L-selectin (CD62L). Anti-Rat L-selectin Antibody (OX-85) inhibits L-selectin in vivo and in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992475
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Radionuclide-Drug Conjugates (RDCs)
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Cancer
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Tecnemab K1 is an anti-Melanoma monoclonal antibody. Tecnemab K1 accumulates in metastatic lesions of malignant melanoma and some benign lesions. When radiolabeled, Tecnemab K1 can serve as a radiotracer for malignant melanoma research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P991841
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IFNAR
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Inflammation/Immunology
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Anti-CD119 Antibody (GIR 208) reacts with the human CD119 (IFN-γ R alpha). IFN-γ exerts its biologic effects by interacting with a single high affinity receptor, IFN-γ receptor. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
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- HY-P992071
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C-type Lectin-like Receptors (CTLRs)
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Inflammation/Immunology
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Anti-Mouse NKG2D Antibody (MI6) is an antibody targeting mouse NKG2D. Anti-Mouse NKG2D Antibody (MI6) can be used in arthritis-related research. For the isotype control of Anti-Mouse NKG2D Antibody (MI6), please refer to Rat IgG1 kappa, Isotype Control (HY-P99979) .
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- HY-P991848
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Fc Receptor (FcR)
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Inflammation/Immunology
|
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Anti-CD64 Antibody (10.1) recognizes an epitope on human CD64 (Fc_RI). Fc gamma receptors (Fc_Rs) are membrane-bound proteins which control and mediate communication of IgG antibodies within the immune system. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991819
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-Mouse ICAM-1 Antibody (BE29G1) reacts with the mouse ICAM-1. Anti-Mouse ICAM-1 Antibody (BE29G1) blocks the binding LFA-1 (CD11a/CD18) to ICAM-1. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P992210
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-CD326 Antibody (17-1A) is a human monoclonal antibody targeting CD326. Anti-CD326 Antibody (17-1A) can be used in cancer research. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).
|
-
- HY-P991854
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-iNKT Cell Antibody (6B11) recognizes an epitope on T cell receptor (TCR) V alpha 24-J alpha 18. Anti-iNKT Cell Antibody is specific for cloned and primary human but not rodent iNKT and the human invariant TCR-α. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991851
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-CD11c Antibody (3.9) recognizes human CD11c. Anti-CD11c Antibody (3.9) blocks CD11c on human peripheral blood mononuclear cell-derived dendritic cells (MoDCs). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991836
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-CD11b Antibody (ICRF44) reacts with the human CD11b. Anti-CD11b Antibody (ICRF44) recognizes the α subunit of the CD11b/CD18 complex, an α/β heterodimeric surface glycoprotein on human leukocytes. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991775
-
|
|
CTLA-4
|
Inflammation/Immunology
|
|
Anti-Rat CTLA-4 Antibody (WKH203) reacts with rat CTLA-4. Anti-Rat CTLA-4 Antibody (WKH203) binds to the CTLA-4 protein disrupts the key signaling mechanisms linked to the suppression of T cell activity, triggering T cells readily and enhancing the immune system’s capacity to identify and eliminate cancer. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991763
-
|
|
SARS-CoV
|
Infection
|
|
Anti-SARS-CoV-2 S protein (RBD) Antibody (SARS2-38) reacts with many variants of SARS-CoV-2 that binds a conserved epitope on the RBD (amino acids K444 and G446). Anti-SARS-CoV-2 S protein (RBD) Antibody (SARS2-38) does not cross-react with the SARS-CoV-1 spike protein. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P992254
-
|
|
LAG-3
|
Cancer
|
|
Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with Kd values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P992244
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL25/IL17E Antibody (ABM109.2) is an antibody targeting IL-25/IL17E, with a Kd of 24 pM for hIL-25 and a Kd of 28 pM for recombinant mouse IL-25. Anti-IL25/IL17E Antibody (ABM109.2) is applicable to research related to inflammatory and immune diseases. The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P992082
-
|
|
VEGFR
|
Cancer
|
|
Anti-Human/Rat VEGF Antibody (A.4.6.1) is an antibody targeting human and rat vascular endothelial growth factor (VEGF) that potently inhibits tumor growth in various animal models. Anti-Human/Rat VEGF Antibody (A.4.6.1) is the parent antibody of Bevacizumab (HY-P9906), and it exhibits high affinity and high selectivity for binding to human VEGF . The isotype control for Anti-Human/Rat VEGF Antibody (A.4.6.1) is Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
- HY-P992146
-
|
MYTX-011 Antibody; Q-397
|
ADC Antibody
c-Met/HGFR
|
Cancer
|
|
Zevontabart (MYTX-011 Antibody; Q-397) is a pH-dependent anti-c-MET antibody. Zevontabart regulates the trafficking process of c-MET to reduce receptor recycling, and enhances its own endocytosis and accumulation in c-MET-expressing cells. Zevontabart induces cytotoxicity in solid tumor cells and exerts anti-tumor activity in a non-small cell lung cancer xenograft mouse model. Zevontabart can be used to synthesize ADC, such as: MYTX-011. Zevontabart can be used in studies related to non-small cell lung cancer, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
- HY-P991762
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Rat CD4 Antibody (W3/25) reacts with rat CD4. Anti-Rat CD4 Antibody (W3/25) inhibits CD4+ T cell activation by downregulating the CD4 molecule on the surface of lymphocytes. Anti-Rat CD4 Antibody (W3/25) inhibits antigen-induced T cell proliferation and IL2 production in MLR experiments. Anti-Rat CD4 Antibody (W3/25) can be used for the study of experimental allergic encephalomyelitis (EAE). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P991749
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity interleukin-2 receptor α chain (IL-2R α, CD25). Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2 with a high affinity (Kd of 0.8 nM) and competes with IL2 binding on this chain (Ki of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P992072
-
|
|
Apoptosis
Caspase
|
Metabolic Disease
|
|
Anti-Human/Mouse CD95 Antibody (HFE7A) is an antibody targeting human/mouse Fas (CD95), with a Kd of 1.6 nM in mice. Anti-Human/Mouse CD95 Antibody (HFE7A) modulates the Fas-mediated apoptotic signaling pathway without blocking the binding of Jo2 to Fas. Anti-Human/Mouse CD95 Antibody (HFE7A) inhibits Jo2-induced caspase activation, mitochondrial depolarization, hepatocyte death and apoptosis. Anti-Human/Mouse CD95 Antibody (HFE7A) protects BALB/c mice against Jo2-induced acute liver injury and reduces Jo2-associated elevation of serum transaminase levels. Anti-Human/Mouse CD95 Antibody (HFE7A) can be used in studies related to liver injury. For isotype control, refer to Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P992426
-
|
|
Tau Protein
|
Neurological Disease
|
|
NS101 is an anti-FAM19A5 antibody with an IC50 of 0.2 nM and a Kd of 111 pM, as well as blood-brain barrier permeability. NS101 binds to key amino acid residues of FAM19A5, thereby blocking the interaction of LRRC4B and disrupting the FAM19A5-LRRC4B complex. NS101 increases the dendritic spine density in hippocampal neurons and the prefrontal cortex, normalizes the dendritic spine elimination rate, elevates the frequencies of mEPSC and fEPSP, and promotes the transport of brain-derived FAM19A5 into the peripheral circulation. NS101 improves cognitive function in mouse models of Alzheimer's disease. NS101 can be used for research on Alzheimer's disease. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P992053
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-CD11a Antibody (MHM24) is a monoclonal antibody targeting murine CD11a. Anti-CD11a Antibody (MHM24) binds to high-affinity (open) and low-affinity (closed) conformations of the αL subunit of LFA-1, and functionally blocks LFA-1-mediated interactions. Anti-CD11a Antibody (MHM24) blocks ICAM-1 binding to LFA-1-expressing cells. Anti-CD11a Antibody (MHM24) inhibits adhesion of high-affinity LFA-1-expressing cells to keratinocytes. Anti-CD11a Antibody (MHM24) inhibits PHA-induced lymphocyte proliferation. Anti-CD11a Antibody (MHM24) can be used for the research of inflammatory and autoimmune diseases. Recommend Isotype Controls: mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
- HY-P992410
-
|
|
PAI-1
TGF-beta/Smad
|
Inflammation/Immunology
|
|
MEDI-579 is a fully human monoclonal antibody against PAI-1, with a KD value of 6 pM for human PAI-1 and 105 pM for rat PAI-1. MEDI-579 restores renal plasmin activity and inhibits PAI-1-mediated intracellular signal transduction. MEDI-579 reduces albuminuria, glomerulosclerosis severity, TGF-β1 expression level, and phosphorylated Smad2 level induced in diabetic mice. MEDI-579 decreases the levels of active PAI-1 in plasma and kidneys, and increases plasma plasmin level in a mouse model of lupus nephritis. MEDI-579 can be used in research related to diabetic nephropathy and lupus nephritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
- HY-P992212
-
|
|
L-Selectin
|
Inflammation/Immunology
|
|
Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977) .
|
-
- HY-P992076
-
|
|
TGF-β Receptor
TGF-beta/Smad
Cholinesterase (ChE)
Fungal
|
Infection
Cancer
|
Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with BChE, and can be used in studies of cryptococcosis and related tumor mechanisms .The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
| Cat. No. |
Product Name |
Target |
Research Area |
Image |
-
- HY-P99977
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Mouse IgG1 kappa, Isotype Control is a negative control reagent/isotype control for mouse-derived IgG1κ antibodies. Mouse IgG1 kappa, Isotype Control, by maintaining the same immunoglobulin structure (including isotype, light chain, etc.) as the specific mouse IgG1κ subtype primary antibody, eliminates false positive signals caused by non-specific binding in immunological experiments, thus playing a core role in verifying the specificity of the experiment. Mouse IgG1 kappa, Isotype Control can be applied to immunolocalization experiments in the field of cell biology, such as immunofluorescence staining and immunohistochemistry, assisting in research on protein subcellular localization and cell structure analysis, ensuring the reliability of experimental results .
|
-
(5)
-
- HY-P99137
-
|
|
IFNAR
|
Inflammation/Immunology
|
|
Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3) .
|
-
(5)
-
- HY-P99983
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Mouse IgG1 (D265A) kappa, Isotype Control is a mouse IgG1(D265A)κ isotype control with a D265A mutation and inactivity against mouse Fc gamma receptors (FcγR1, FcγR2, FcγR3, FcγR4) .
|
-
(5)
-
- HY-P991446
-
|
|
Influenza Virus
|
Infection
|
|
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P991481
-
|
|
CCR
|
Inflammation/Immunology
Cancer
|
|
S-531011 is a human IgG1 monoclonal antibody (mAb) targeting CCR8. S-531011 reduces tumor-infiltrating CCR8+ Tregs and has anti-tumor activity in CT26.WT and EMT6 tumor-bearing mouse tumor models. S-531011 can be used in the study of cancer immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P990870
-
|
|
CD19
IFNAR
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-CD19 Antibody (4G7) is an anti-human CD19 IgG1 monoclonal antibody. Anti-CD19 Antibody (4G7) reduces the killing effect of CAR T cells on Raji cells. Anti-CD19 Antibody (4G7) can be used for research on immunology. Anti-CD19 Antibody (4G7) is often used in flow cytometry. The recommend isotype control of Anti-CD19 Antibody (4G7): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P991278
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
ABM-125 is a IL-25 neutralizer and immune response modulator. ABM-125 neutralizes human and mouse IL-25 and blocks type 2 immune activation function. ABM-125 regulates virus-induced inflammatory cytokine expression and increases the expression level of antiviral interferons in rhinovirus-infected asthmatic bronchial epithelial cells. For the isotype control of ABM-125, refer to Human IgG1 kappa, Isotype Control (HY-P99001). ABM-125 is applicable to research related to virus-induced acute asthma exacerbations .
|
-
(5)
-
- HY-P990953
-
|
Gen1047
|
CD3
|
Cancer
|
|
Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of B7H4-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of B7H4-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer) .
|
-
(5)
-
- HY-P99984
-
-
(5)
-
- HY-P990572
-
DCBY02
1 Publications Verification
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
DCBY02 is a monoclonal antibody targeting CD93 expressed in CHO cells. DCBY02 has a heavy chain of the mlgG type and a light chain of the mkappa type, with a predicted molecular weight (MW) of 150 kDa. The isotype control for DCBY02 can be referenced as Mouse IgG1 kappa, Isotype Control.
|
-
(5)
-
- HY-P990552
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
ATN-658 is a mouse-derived IgG antibody expressed in CHO cells that targets PLAUR/uPAR/CD87. ATN-658 contains muIgG1 heavy chain and mκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for ATN-658 can be referenced as Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P990797
-
|
|
IFNAR
|
Infection
Inflammation/Immunology
|
|
Anti-Mouse IFN gamma Antibody (R4-6A2) is an anti-mouse IFN gamma IgG1 monoclonal antibody. Anti-Mouse IFN gamma Antibody (R4-6A2) can increase the total serum IgG level. Anti-Mouse IFN gamma Antibody (R4-6A2) can be used for researches on immunology and infection conditions such as nymphs infection. The recommend isotype control of Anti-Mouse IFN gamma Antibody (R4-6A2): Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P990818
-
|
|
Fc Receptor (FcR)
|
Inflammation/Immunology
|
|
Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can effectively bind to FcRn and competitively inhibit the binding of IgG to FcRn. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can reduce the total serum IgG level. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can be used for researches on autoimmune conditions such as experimental autoimmune myasthenia gravis (EAMG). The recommend isotype control of Anti-Rat FcRn heavy chain heterodimers Antibody (1G3): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P990599
-
|
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Ibritumomab is a mouse antibody expressed in CHO, targeting CD20/MS4A1. Ibritumomab is equipped with a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Ibritumomab can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
-
- HY-P991447
-
|
|
VISTA
|
Cancer
|
|
Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991842
-
|
|
CD3
|
Inflammation/Immunology
|
|
Anti-CD3 Antibody (UCHT-1) reacts with human CD3ε. Anti-CD3 Antibody (UCHT-1) can be used for the study of graft-versus-host disease (GVHD). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P991792
-
|
|
Phosphatase
|
Cancer
|
|
Anti-Rat pan-CD45 Antibody (OX1) reacts with a common epitope present on all isotypes of rat CD45. CD45 is largely expressed in the lymphoid system, but it is also found in all hematopoietic cells except erythrocytes and platelets. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P990800
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-Mouse IL-4 Antibody (BVD6-24G2) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (BVD6-24G2) can inhibit IL-4 signaling and promote Treg differentiation. Anti-Mouse IL-4 Antibody (BVD6-24G2) can be used for research on immunology. The recommend isotype control of Anti-Mouse IL-4 Antibody (BVD6-24G2): Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P991750
-
|
|
MHC
|
Inflammation/Immunology
|
|
Anti-pan MHC Class II (HLA II) Antibody (IVA12) recognizes human HLA-II (HLA-DR, HLA-DP, and HLA-DQ). Anti-pan MHC Class II (HLA II) Antibody (IVA12) blocks MHC-II in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P990400
-
|
|
Discoidin Domain Receptor
|
Inflammation/Immunology
|
|
Anti-DDR1/CD167a Antibody is a CHO-expressed antibody that targets DDR1/CD167a. The Anti-DDR1/CD167a Antibody has a mouse IgG1 type heavy chain and a mouse κ type light chain, with a predicted molecular weight (MW) of 143.32 kDa. The isotype control for Anti-DDR1/CD167a Antibody can refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P990241
-
|
|
TNF Receptor
|
Inflammation/Immunology
Cancer
|
|
Anti-Mouse GITR (D265A) Antibody (DTA-1) is an anti-mouse GITR IgG1 monoclonal antibody. Anti-Mouse GITR (D265A) Antibody (DTA-1) is a chimeric antibody of the original DTA-1 antibody (HY-P990124). Anti-Mouse GITR (D265A) Antibody (DTA-1) contains the D265A mutation region. Anti-Mouse GITR (D265A) Antibody (DTA-1) can be used for research on cancer and allergic conditions. The recommed isotype control of Anti-Mouse GITR (D265A) Antibody (DTA-1) is Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991310
-
|
LT3015; LT-3000
|
LPL Receptor
|
Neurological Disease
Cancer
|
|
Lpathomab (LT3015; LT-3000) is a human IgG1 monoclonal antibody (mAb) targeting LPA. Lpathomab reduces the release of IL-8 and IL-6 cytokines in SKOV3 cells and blocks LPA-triggered tumor cell migration. Lpathomab reduces neovascularization in Matrigel plug and CNV models. Lpathomab inhibits brain injury in the CCI mouse model. Lpathomab can be used in the study of brain injury, ovarian cancer, diabetic neuropathy, and spinal cord injury. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P990869
-
|
|
CD1
IFNAR
Interleukin Related
|
Inflammation/Immunology
Cancer
|
|
Anti-CD1a Antibody (OKT-6) is an anti-human CD1a IgG1 monoclonal antibody. Anti-CD1a Antibody (OKT-6) blocks T cell activation by blocking CD1a function. Anti-CD1a Antibody (OKT-6) can reduce the production of IFN-γ. Anti-CD1a Antibody (OKT-6) can be used for researches on cancer and inflammation such as leukemia. The recommend isotype control of Anti-CD1a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P990867
-
|
|
Insulin Receptor
Akt
|
Cancer
|
|
Anti-CD220/Insulin Receptor Antibody (IR 83-22) is an anti-human CD220/Insulin Receptor IgG1 monoclonal antibody. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can block Akt overactivation caused by Trip13 deficiency. Anti-CD220/Insulin Receptor Antibody (IR 83-22) can be used for research on cancer such as hepatocellular carcinoma (HCC). Anti-CD220/Insulin Receptor Antibody (IR 83-22) often used in western blotting. The recommend isotype control of Anti-CD220/Insulin Receptor Antibody (IR 83-22): Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P991425
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
AT-1413 is a human monoclonal antibody (mAb) targeting CD43. AT-1413 induces antibody-dependent cell-mediated cytotoxicity (ADCC) in melanoma cell lines and acute myeloid leukemia (AML) cells. AT-1413 has antitumor activity in AML mouse models. AT-1413 can be used in Acute myeloid leukaemia, Breast cancer, Malignant melanoma and Myelodysplastic syndromes research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P991468
-
|
|
Interleukin Related
|
Cancer
|
|
IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC50 values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
-
- HY-P992203
-
|
|
CD47
|
Others
|
|
Anti-CD172a Antibody (3F9) is a humanized IgG1 monoclonal antibody targeting SIRPα/CD172a. The recommended isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991992
-
|
|
Thrombin
|
Cardiovascular Disease
|
|
Anti-Factor X Antibody is an anti-Factor X antibody. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991890
-
|
|
CD1
|
Inflammation/Immunology
|
|
Anti-CD1a Antibody is an antibody against human CD1a. Recommend Isotype Controls:?Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991784
-
|
|
EGFR
|
Cancer
|
|
Anti-Mouse/Human EGFR (domain III) Antibody (EMab-88) reacts with domain III of the mouse and human EGFR. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P992196
-
|
|
CD28
|
Inflammation/Immunology
|
|
Anti-Canine CD28 Antibody (1C6) is a mouse-derived monoclonal antibody that targets canine CD28, which isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P992070
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Others
|
|
Anti-Human/Mouse NKG2D Antibody (ADI-27740) is an antibody targeting human/mouse NKG2D. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991822
-
|
|
MHC
|
Inflammation/Immunology
|
|
Anti-Mouse H-2b Antibody (B8-24-3) reacts with the mouse H-2b. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P992271
-
|
|
GDNF Receptor
|
Inflammation/Immunology
|
|
Anti-Neublastin Antibody is a monoclonal antibody targeting neublastin. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Neublastin Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991753
-
|
|
CXCR
|
Inflammation/Immunology
|
|
Anti-Mouse CCL5 Antibody (R6G9) reacts with mouse CCL5 that can neutralize CCL5 both in vitro and in vivo. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P991834
-
|
|
Integrin
|
Cardiovascular Disease
|
|
Anti-Mouse CD41 Antibody (S-R690) reacts with mouse CD41. CD41 is a crucial protein involved in platelet aggregation and hemostasis. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).
|
-
(5)
-
- HY-P991825
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-Mouse CD18 Antibody (C71/16) reacts with an epitope on mouse CD18. CD18 is the Integrin β2 chain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P991781
-
|
|
CXCR
|
Inflammation/Immunology
|
|
Anti-Mouse CXCR6 Antibody (Cx6Mab-1) reacts with the N-terminal extracellular ligand-binding domain of mouse CXCR6. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P991833
-
|
|
CD28
|
Inflammation/Immunology
|
|
Anti-Mouse BTLA/CD272 Antibody (PK18.6) reacts with mouse B- and T-lymphocyte attenuator (BTLA). BTLA is an Ig superfamily member. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P991757
-
|
|
PSMA
|
Cancer
|
|
Anti-Human/Mouse/Rat/Canine/Swine PSMA Antibody (3F11) reacts with prostate-specific membrane antigen (PSMA) from human, mouse, rat, canine and swine species. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P991765
-
|
|
VISTA
|
Inflammation/Immunology
|
|
Anti-VISTA Antibody (GG8) reacts with human VISTA. Endogenous VISTA has inhibitory effects both as a ligand on APCs and as a receptor on T cells. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P992069
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Others
|
|
Anti-Human/Mouse NKG2D Antibody (ADI-27724) is an antibody targeting human/mouse NKG2D. The isotype control for Anti-Human/Mouse NKG2D Antibody (ADI-27724) can be referenced as Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991745
-
|
|
CCR
|
Inflammation/Immunology
|
|
Anti-Mouse CCR2 Antibody (C2Mab-6) is raised against and binds to the N-terminal sequence of CCR2. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P992013
-
|
|
CXCR
|
Others
|
|
Anti-CXCR3 Antibody (5H7) is a mouse monoclonal antibody produced using CXCR3 as the antigen. The recommended isotype control is human IgG1 kappa (HY-P99001).
|
-
(5)
-
- HY-P992277
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-NKp46 Antibody is a monoclonal antibody targeting NKp46. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NKp46 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P992240
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-19 Antibody is a monoclonal antibody that targets IL-19. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-19 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991783
-
|
|
EGFR
|
Cancer
|
|
Anti-Mouse EGFR (domain I) Antibody (EMab-300) reacts with domain I of the mouse EGFR. Anti-Mouse EGFR (domain I) Antibody (EMab-300) applies to the detection of mouse EGFR using flow cytometry. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
-
- HY-P991759
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Rat CD86 Antibody (OX-48) recognizes CD86, thereby blocking the binding of CD86 to CD28, and thus inhibiting T cell proliferation. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
-
- HY-P992207
-
|
|
SHP1
|
Inflammation/Immunology
|
|
Anti-CD300A Antibody is a monoclonal antibody targeting CD300A. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD300A Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
-
- HY-P991793
-
|
|
Phosphatase
|
Inflammation/Immunology
|
|
Anti-Rat CD45RC Antibody (OX22) reacts with rat CD45RC. CD45RC molecule is involved in lymphocyte signaling and is associated with inflammatory responses. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991840
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-CD68 Antibody (KP1) is a anti-CD68 monoclonal antibody (mAb). CD68 is present in various cell types, including monocytes/macrophages and fibroblasts. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992068
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Others
|
|
Anti-Human/Monkey NKG2D Antibody (ON72) is an antibody targeting human/monkey NKG2D. The isotype control for Anti-Human/Monkey NKG2D Antibody (ON72) can be referenced as Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
- HY-P991853
-
|
|
Prostaglandin Receptor
|
Inflammation/Immunology
|
|
Anti-MSMP/PSMP Antibody (3D5) reacts with human MSMP (Prostate-associated microsemino protein). Anti-MSMP/PSMP Antibody (3D5) significantly ameliorates fibrosis in mice. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991815
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Mouse CD90.1 Antibody (OX-7) reacts with the mouse and rat CD90.1. CD90 is present on a variety of cell types in murine and rat, including lymphatic vessels, T cells, neurons and fibroblasts. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992273
-
|
|
Trk Receptor
|
Inflammation/Immunology
|
|
Anti-NGF2 Antibody is a monoclonal antibody targeting NGF2/NT-3. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NGF2 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
- HY-P991752
-
|
|
CXCR
|
Cancer
|
|
Anti-Mouse CXCL16 Antibody (12-81) reacts with the extracellular domain of CXCL16. Anti-Mouse CXCL16 Antibody (12-81) can neutralize CXCL16/SR-PSOX both in vitro and in vivo. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
- HY-P991780
-
|
|
EGFR
|
Cancer
|
|
Anti-Mouse HER2 (domain I) Antibody (H2Mab-304) reacts with domain I of mouse HER2. HER2 is a 185 kDa transmembrane receptor tyrosine kinase that is part of the EGFR family. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979).
|
-
(5)
- HY-P991818
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Inflammation/Immunology
|
|
Anti-Mouse CD370 Antibody (1F6) reacts with the mouse CD370 (also known as CLEC9A or DNGR1). CD370 is a type II membrane protein with a single extracellular C-type lectin domain. Recommend Isotype Controls: Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
- HY-P991847
-
|
|
PD-1/PD-L1
|
Cancer
|
|
Anti-PD-L2 Antibody (3.2) recognizes an epitope on mouse and human PD-L2. PD-L2 is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992289
-
|
|
PD-1/PD-L1
|
Inflammation/Immunology
|
|
Anti-PD-L2 Antibody is a monoclonal antibody targeting PD-L2/CD273. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-PD-L2 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
- HY-P991838
-
|
|
Transferrin Receptor
|
Cancer
|
|
Anti-CD71 Antibody (T56/14) reacts with human CD71. Anti-CD71 Antibody (T56/14) is a non-neutralizing antibody that does not inhibit the binding of transferrin. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991755
-
|
|
CD47
|
Neurological Disease
|
|
Anti-Rat CD47 Antibody (OX-101) reacts with CD47. Anti-Rat CD47 Antibody (OX-101) accelerates hematoma clearance and alleviates hydrocephalus after experimental intraventricular hemorrhage. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991794
-
|
|
L-Selectin
|
Cancer
|
|
Anti-Rat L-selectin Antibody (OX-85) reacts with rat L-selectin (CD62L). Anti-Rat L-selectin Antibody (OX-85) inhibits L-selectin in vivo and in vitro. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992475
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
Tecnemab K1 is an anti-Melanoma monoclonal antibody. Tecnemab K1 accumulates in metastatic lesions of malignant melanoma and some benign lesions. When radiolabeled, Tecnemab K1 can serve as a radiotracer for malignant melanoma research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991841
-
|
|
IFNAR
|
Inflammation/Immunology
|
|
Anti-CD119 Antibody (GIR 208) reacts with the human CD119 (IFN-γ R alpha). IFN-γ exerts its biologic effects by interacting with a single high affinity receptor, IFN-γ receptor. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992071
-
|
|
C-type Lectin-like Receptors (CTLRs)
|
Inflammation/Immunology
|
|
Anti-Mouse NKG2D Antibody (MI6) is an antibody targeting mouse NKG2D. Anti-Mouse NKG2D Antibody (MI6) can be used in arthritis-related research. For the isotype control of Anti-Mouse NKG2D Antibody (MI6), please refer to Rat IgG1 kappa, Isotype Control (HY-P99979) .
|
-
(5)
- HY-P991848
-
|
|
Fc Receptor (FcR)
|
Inflammation/Immunology
|
|
Anti-CD64 Antibody (10.1) recognizes an epitope on human CD64 (Fc_RI). Fc gamma receptors (Fc_Rs) are membrane-bound proteins which control and mediate communication of IgG antibodies within the immune system. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991819
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-Mouse ICAM-1 Antibody (BE29G1) reacts with the mouse ICAM-1. Anti-Mouse ICAM-1 Antibody (BE29G1) blocks the binding LFA-1 (CD11a/CD18) to ICAM-1. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992210
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
Anti-CD326 Antibody (17-1A) is a human monoclonal antibody targeting CD326. Anti-CD326 Antibody (17-1A) can be used in cancer research. The recommended isotype control is Mouse IgG1 kappa (HY-P99977).
|
-
(5)
- HY-P991854
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-iNKT Cell Antibody (6B11) recognizes an epitope on T cell receptor (TCR) V alpha 24-J alpha 18. Anti-iNKT Cell Antibody is specific for cloned and primary human but not rodent iNKT and the human invariant TCR-α. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991851
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-CD11c Antibody (3.9) recognizes human CD11c. Anti-CD11c Antibody (3.9) blocks CD11c on human peripheral blood mononuclear cell-derived dendritic cells (MoDCs). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991836
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-CD11b Antibody (ICRF44) reacts with the human CD11b. Anti-CD11b Antibody (ICRF44) recognizes the α subunit of the CD11b/CD18 complex, an α/β heterodimeric surface glycoprotein on human leukocytes. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991775
-
|
|
CTLA-4
|
Inflammation/Immunology
|
|
Anti-Rat CTLA-4 Antibody (WKH203) reacts with rat CTLA-4. Anti-Rat CTLA-4 Antibody (WKH203) binds to the CTLA-4 protein disrupts the key signaling mechanisms linked to the suppression of T cell activity, triggering T cells readily and enhancing the immune system’s capacity to identify and eliminate cancer. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991763
-
|
|
SARS-CoV
|
Infection
|
|
Anti-SARS-CoV-2 S protein (RBD) Antibody (SARS2-38) reacts with many variants of SARS-CoV-2 that binds a conserved epitope on the RBD (amino acids K444 and G446). Anti-SARS-CoV-2 S protein (RBD) Antibody (SARS2-38) does not cross-react with the SARS-CoV-1 spike protein. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992254
-
|
|
LAG-3
|
Cancer
|
|
Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with Kd values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992244
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL25/IL17E Antibody (ABM109.2) is an antibody targeting IL-25/IL17E, with a Kd of 24 pM for hIL-25 and a Kd of 28 pM for recombinant mouse IL-25. Anti-IL25/IL17E Antibody (ABM109.2) is applicable to research related to inflammatory and immune diseases. The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P992082
-
|
|
VEGFR
|
Cancer
|
|
Anti-Human/Rat VEGF Antibody (A.4.6.1) is an antibody targeting human and rat vascular endothelial growth factor (VEGF) that potently inhibits tumor growth in various animal models. Anti-Human/Rat VEGF Antibody (A.4.6.1) is the parent antibody of Bevacizumab (HY-P9906), and it exhibits high affinity and high selectivity for binding to human VEGF . The isotype control for Anti-Human/Rat VEGF Antibody (A.4.6.1) is Mouse IgG1 kappa, Isotype Control (HY-P99977).
|
-
(5)
- HY-P992146
-
|
MYTX-011 Antibody; Q-397
|
ADC Antibody
c-Met/HGFR
|
Cancer
|
|
Zevontabart (MYTX-011 Antibody; Q-397) is a pH-dependent anti-c-MET antibody. Zevontabart regulates the trafficking process of c-MET to reduce receptor recycling, and enhances its own endocytosis and accumulation in c-MET-expressing cells. Zevontabart induces cytotoxicity in solid tumor cells and exerts anti-tumor activity in a non-small cell lung cancer xenograft mouse model. Zevontabart can be used to synthesize ADC, such as: MYTX-011. Zevontabart can be used in studies related to non-small cell lung cancer, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001) .
|
-
(5)
- HY-P991762
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Rat CD4 Antibody (W3/25) reacts with rat CD4. Anti-Rat CD4 Antibody (W3/25) inhibits CD4+ T cell activation by downregulating the CD4 molecule on the surface of lymphocytes. Anti-Rat CD4 Antibody (W3/25) inhibits antigen-induced T cell proliferation and IL2 production in MLR experiments. Anti-Rat CD4 Antibody (W3/25) can be used for the study of experimental allergic encephalomyelitis (EAE). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P991749
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity interleukin-2 receptor α chain (IL-2R α, CD25). Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2 with a high affinity (Kd of 0.8 nM) and competes with IL2 binding on this chain (Ki of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992072
-
|
|
Apoptosis
Caspase
|
Metabolic Disease
|
|
Anti-Human/Mouse CD95 Antibody (HFE7A) is an antibody targeting human/mouse Fas (CD95), with a Kd of 1.6 nM in mice. Anti-Human/Mouse CD95 Antibody (HFE7A) modulates the Fas-mediated apoptotic signaling pathway without blocking the binding of Jo2 to Fas. Anti-Human/Mouse CD95 Antibody (HFE7A) inhibits Jo2-induced caspase activation, mitochondrial depolarization, hepatocyte death and apoptosis. Anti-Human/Mouse CD95 Antibody (HFE7A) protects BALB/c mice against Jo2-induced acute liver injury and reduces Jo2-associated elevation of serum transaminase levels. Anti-Human/Mouse CD95 Antibody (HFE7A) can be used in studies related to liver injury. For isotype control, refer to Mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992426
-
|
|
Tau Protein
|
Neurological Disease
|
|
NS101 is an anti-FAM19A5 antibody with an IC50 of 0.2 nM and a Kd of 111 pM, as well as blood-brain barrier permeability. NS101 binds to key amino acid residues of FAM19A5, thereby blocking the interaction of LRRC4B and disrupting the FAM19A5-LRRC4B complex. NS101 increases the dendritic spine density in hippocampal neurons and the prefrontal cortex, normalizes the dendritic spine elimination rate, elevates the frequencies of mEPSC and fEPSP, and promotes the transport of brain-derived FAM19A5 into the peripheral circulation. NS101 improves cognitive function in mouse models of Alzheimer's disease. NS101 can be used for research on Alzheimer's disease. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P992053
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-CD11a Antibody (MHM24) is a monoclonal antibody targeting murine CD11a. Anti-CD11a Antibody (MHM24) binds to high-affinity (open) and low-affinity (closed) conformations of the αL subunit of LFA-1, and functionally blocks LFA-1-mediated interactions. Anti-CD11a Antibody (MHM24) blocks ICAM-1 binding to LFA-1-expressing cells. Anti-CD11a Antibody (MHM24) inhibits adhesion of high-affinity LFA-1-expressing cells to keratinocytes. Anti-CD11a Antibody (MHM24) inhibits PHA-induced lymphocyte proliferation. Anti-CD11a Antibody (MHM24) can be used for the research of inflammatory and autoimmune diseases. Recommend Isotype Controls: mouse IgG1 kappa, Isotype Control (HY-P99977) .
|
-
(5)
- HY-P992410
-
|
|
PAI-1
TGF-beta/Smad
|
Inflammation/Immunology
|
|
MEDI-579 is a fully human monoclonal antibody against PAI-1, with a KD value of 6 pM for human PAI-1 and 105 pM for rat PAI-1. MEDI-579 restores renal plasmin activity and inhibits PAI-1-mediated intracellular signal transduction. MEDI-579 reduces albuminuria, glomerulosclerosis severity, TGF-β1 expression level, and phosphorylated Smad2 level induced in diabetic mice. MEDI-579 decreases the levels of active PAI-1 in plasma and kidneys, and increases plasma plasmin level in a mouse model of lupus nephritis. MEDI-579 can be used in research related to diabetic nephropathy and lupus nephritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
|
-
(5)
- HY-P992212
-
|
|
L-Selectin
|
Inflammation/Immunology
|
|
Anti-CD62L Antibody (DREG-200) is a human monoclonal antibody targeting CD62L/L-selectin. Anti-CD62L Antibody (DREG-200) binds to residues 45, 46 and 47 of L-selectin, and blocks L-selectin-mediated interactions, neutrophil rolling, adhesion, aggregation, secondary anchoring, as well as leukocyte rolling on ligands. Anti-CD62L Antibody (DREG-200) reduces myocardial necrosis, coronary endothelial dysfunction, and neutrophil migration driven by neutrophil microparticles. Anti-CD62L Antibody (DREG-200) exerts cardioprotective effects in feline models. Anti-CD62L Antibody (DREG-200) can be used in studies related to myocardial ischemia-reperfusion injury. The recommended isotype control is Mouse IgG1 kappa (HY-P99977) .
|
-
(5)
- HY-P992076
-
|
|
TGF-β Receptor
TGF-beta/Smad
Cholinesterase (ChE)
Fungal
|
Infection
Cancer
|
Anti-Candida auris β-1,3-glucans Antibody (2G8) is an antibody targeting Candida auris β-1,3-glucans, and also acts as an inhibitor of AChE and TGF-β receptor 2. Anti-Candida auris β-1,3-glucans Antibody (2G8) also targets fungal cell wall components, effectively inhibits fungal growth and interferes with capsule formation, thereby significantly reducing the fungal load in mouse tissues. Anti-Candida auris β-1,3-glucans Antibody (2G8) not only blocks TGF-β receptor binding to inhibit the Smad signaling pathway, reduces fibroblast activation and collagen deposition, but also induces epithelial differentiation of tumor cells and reduces pancreatic tumor metastasis. Anti-Candida auris β-1,3-glucans Antibody (2G8) specifically binds to the conserved N-linked glycoepitope on AChE to inhibit its activity without interfering with BChE, and can be used in studies of cryptococcosis and related tumor mechanisms .The isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
|
-
(5)
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