2. Inhibitory Antibodies
  3. Isotype Control Antibodies
  4. Mouse IgG1 (D265A) kappa, Isotype Control

Mouse IgG1 (D265A) kappa, Isotype Control 

Cat. No.: HY-P99983 Purity: 99.52%
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SDS
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Mouse IgG1 (D265A) kappa, Isotype Control is a mouse IgG1(D265A)κ isotype control with a D265A mutation and inactivity against mouse Fc gamma receptors (FcγR1, FcγR2, FcγR3, FcγR4).

For research use only. We do not sell to patients.

Mouse IgG1 (D265A) kappa, Isotype Control

Mouse IgG1 (D265A) kappa, Isotype Control Chemical Structure

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Mouse IgG1 (D265A) kappa, Isotype Control Related Antibodies

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  • Biological Activity

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Description

Mouse IgG1 (D265A) kappa, Isotype Control is a mouse IgG1(D265A)κ isotype control with a D265A mutation and inactivity against mouse Fc gamma receptors (FcγR1, FcγR2, FcγR3, FcγR4)[1].

In Vitro

The CD3/CD20 bispecific form of Mouse IgG1 (D265A) kappa, Isotype Control binds to CHO cells expressing mouse CD20 and primary mouse CD3+ T cells in a dose-dependent manner, as detected by flow cytometry[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mouse IgG1 (D265A) kappa, Isotype Control Related Antibodies
In Vivo

Mouse IgG1 (D265A) kappa, Isotype Control (1 mg/kg; single dose) does not deplete circulating or spleen B-cells in wild-type C57BL/6 mice, with B-cell numbers remaining stable over 7 days after treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Mouse IgG1 (D265A) kappa, Isotype Control]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mouse IgG1 (D265A) kappa, Isotype Control Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mouse IgG1 (D265A) kappa, Isotype ControlOthersmouse A20 B-cell lymphoma cellsprimary mouse CD3+ T-cellsmouse FcRnFcγR4FcγR1CHO cellsmouse CD20mouse Fc gamma receptorsFcγR2FcγR3Inhibitorinhibitorinhibit

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Mouse IgG1 (D265A) kappa, Isotype Control
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