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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
NLRP1
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "NLRP1" in MCE Product Catalog:
11
Target:
Research Areas:
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist [1] .
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4 Cited Publications
Research Areas:
ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases [1].
Cat. No.: HY-RS09349
Target:
Research Areas:
NLRP1 Human Pre-designed siRNA Set A contains three designed siRNAs for NLRP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: 7-Desacetoxy-6,7-dehydrogedunin
Target:
PERK Prokineticin Receptor P2X Receptor Caspase NOD-like Receptor (NLR) Pyroptosis Tyrosinase
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders [1] .
Cat. No.: HY-RS09355
Target:
Research Areas:
Nlrp1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Nlrp1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09354
Target:
Research Areas:
Nlrp1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nlrp1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702188
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NLRP1; Nucleotide-Binding Domain And Caspase Recruitment Domain; Prev. NALP1; DKFZp586O1822; Prev. SLEV1; Systemic Lupus Erythematosus, Vitiligo-Related 1; DEFCAP; NACHT, Leucine Rich Repeat And PYD Containing 1; CARD7; NACHT, LRR And PYD Containing Prote
Cat. No.: HY-P702189
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NLRP1; Nucleotide-Binding Domain And Caspase Recruitment Domain; Prev. NALP1; DKFZp586O1822; Prev. SLEV1; Systemic Lupus Erythematosus, Vitiligo-Related 1; DEFCAP; NACHT, Leucine Rich Repeat And PYD Containing 1; CARD7; NACHT, LRR And PYD Containing Prote
Cat. No.: HY-178898
CAS No.: 13072-74-7
Cat. No.: HY-127090S
Synonyms: MDP-d3
Cat. No.: HY-L175
176 compounds
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.
MCE designs a unique collection of 176 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.
Cat. No.: HY-P89570
Synonyms: CARD7, DEFCAP, KIAA0926, NAC, NALP1, NLRP1, Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
