26927-01-5
Chemical Structure
7DG
Synonym(s): 7-Desacetoxy-6,7-dehydrogedunin
- CAS No.: 26927-01-5
- Formula:C26H30O5
- Molecular Weight:422.51
IUPAC Name: (1S,3aS,4aS,4bR,6aR,10aR,10bR,12aS)-1-(furan-3-yl)-4b,7,7,10a,12a-pentamethyl-1,6a,7,10a,10b,11,12,12a-octahydronaphtho[2,1-f]oxireno[2,3-d]isochromene-3,8(3aH,4bH)-dione
InChIKey: ZXHLDNILIVGKPC-WOERNGHISA-N
SMILES: O=C1O[C@@H](C2=COC=C2)[C@]3(C)CC[C@@]4([H])[C@](C=C[C@@]5([H])C(C)(C)C(C=C[C@@]54C)=O)(C)[C@@]36[C@@H]1O6
Biological Activity: 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders[1][2][3].
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7DG | 98% | 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders. | ||||||||||||||||||||
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- [1]. Hett EC, et al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013;9(6):398-405. [Content Brief]
- [2]. Chukwurah E, et al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021;288(22):6365-6391. [Content Brief]
- [3]. Park S, et al. 7-desacetoxy-6,7-dehydrogedunin discovered by high-throughput screening system suppresses melanogenesis through ATP-P2X7 signaling inhibition. J Dermatol Sci. 2022;108(3):157-166. [Content Brief]
Keywords
