6 Results for "

PDX1 cells

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "PDX1 cells" in MCE Product Catalog:

Cat. No.: HY-133668
CAS No.: 2306-33-4
Purity:  96.78%
Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .
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Cat. No.: HY-19694
CAS No.: 1137359-47-7
Target:  

Insulin Receptor

Research Areas:  

Endocrinology

BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function .
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Cat. No.: HY-133668S
CAS No.: 1219806-03-7
Purity:  98.27%
Monoethyl phthalate-d4 is the deuterium labeled Monoethyl phthalate. Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .
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Cat. No.: HY-N19830
CAS No.: 585527-12-4
Guavenoic acid is a triterpenoid compound that can be isolated from fresh leaves of Psidium guajava. Guavenoic acid protects cells in cellular oxidative damage models, inhibits intracellular ROS production, and suppresses cell apoptosis. Guavenoic acid significantly enhances cellular proliferation, promotes insulin synthesis and secretion, and upregulates the messenger RNA expression of insulin gene, PDX-1 and MafA. Guavenoic acid can be used in the research of diseases such as pancreatic islet β-cell tumors .
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Cat. No.: HY-P991294

Target:  

ADC Antibodies

Research Areas:  

Cancer

MGTA-117 is a humanized monoclonal antibody targeting CD117. MGTA-117 can be used for synthesis of antibody-drug conjugate (ADC), utilizing an amanitin payload. MGTA-117 has potent anti-tumor activity and increases survival in three acute myeloid leukemia (AML) xenograft hNSG mice models (Kasumi-1, AML PDX 1 and AML PDX 2). MGTA-117 enables hematopoietic stem cell transplantation (HSCT) preprocessing in AML, myelodysplasia with excess blasts (MDS-EB) and gene therapy .
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Cat. No.: HY-W1130459
CAS No.: 1226777-45-2
Target:  

Liposome

Research Areas:  

Cancer

(R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .
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