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BRD7552 

Cat. No.: HY-19694
Handling Instructions

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

For research use only. We do not sell to patients.

BRD7552 Chemical Structure

BRD7552 Chemical Structure

CAS No. : 1137359-47-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 150 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 960 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. Target: PDX1 [1] in vitro: BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.4052 mL 7.0261 mL 14.0522 mL
5 mM 0.2810 mL 1.4052 mL 2.8104 mL
10 mM 0.1405 mL 0.7026 mL 1.4052 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

711.63

Formula

C₃₃H₃₃N₃O₁₅

CAS No.

1137359-47-7

SMILES

OC[[email protected]@H](O1)[[email protected]@H](OC(NC2=CC=C(C(OCC)=O)C=C2)=O)[[email protected]](OC(NC3=CC=C(OCO4)C4=C3)=O)[[email protected]@H](OC(NC5=CC=C(OCO6)C6=C5)=O)[[email protected]]1OC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 38 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BRD7552
Cat. No.:
HY-19694
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