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BRD7552 

Cat. No.: HY-19694 Purity: >98.0%
Handling Instructions

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

For research use only. We do not sell to patients.

BRD7552 Chemical Structure

BRD7552 Chemical Structure

CAS No. : 1137359-47-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. Target: PDX1 [1] in vitro: BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

Molecular Weight

711.63

Formula

C₃₃H₃₃N₃O₁₅

CAS No.

1137359-47-7

SMILES

OC[[email protected]@H](O1)[[email protected]@H](OC(NC2=CC=C(C(OCC)=O)C=C2)=O)[[email protected]](OC(NC3=CC=C(OCO4)C4=C3)=O)[[email protected]@H](OC(NC5=CC=C(OCO6)C6=C5)=O)[[email protected]]1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (140.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4052 mL 7.0261 mL 14.0522 mL
5 mM 0.2810 mL 1.4052 mL 2.8104 mL
10 mM 0.1405 mL 0.7026 mL 1.4052 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BRD7552BRD 7552BRD-7552OthersInhibitorinhibitorinhibit

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Product Name:
BRD7552
Cat. No.:
HY-19694
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