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Cat. No.: HY-N19830

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Guavenoic acid

Guavenoic acid is a triterpenoid compound that can be isolated from fresh leaves of Psidium guajava. Guavenoic acid protects cells in cellular oxidative damage models, inhibits intracellular ROS production, and suppresses cell apoptosis. Guavenoic acid significantly enhances cellular proliferation, promotes insulin synthesis and secretion, and upregulates the messenger RNA expression of insulin gene, PDX-1 and MafA. Guavenoic acid can be used in the research of diseases such as pancreatic islet β-cell tumors.

For research use only. We do not sell to patients.

CAS No.: 585527-12-4
Formula: C₃₀H₄₆O₆
Molecular Weight:502.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Guavenoic acid Chemical Structure

CAS No.: 585527-12-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Guavenoic acid (0.3-30 nM, 48 h) protects cells, inhibits intracellular ROS production, and suppresses cell apoptosis in the H₂O₂-induced oxidative damage model of INS-1 cells^[2].
Guavenoic acid (0.3-30 nM, 48 h) promotes the proliferation of INS-1 cells, enhances cellular insulin synthesis capacity, strengthens both basal insulin secretion and glucose-stimulated insulin secretion functions, and upregulates the mRNA expression levels of insulin gene, PDX-1, and MafA in INS-1 cells under a glucose-stimulated insulin secretion model with glucose concentrations of 5.6 and 16.7 mM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

650 μM H₂O₂ challenges the INS-1 cells
Concentration:

0.3, 1, 3, 10, 30 nM
Incubation Time:

48 h
Result:

Suppresses cell apoptosis.

Chemical Information

CAS No. 585527-12-4
Molecular Weight 502.68
Formula C₃₀H₄₆O₆
SMILES

C[C@@]12[C@]3([H])[C@]([C@]4(C([C@@]5([H])[C@@](CC4)(CCC([C@@H]5C)=C)C(O)=O)=CC3)C)(C[C@H]([C@@]1([H])[C@@](C)([C@H]([C@@H](C2)O)O)CO)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Begum S, et al. Two new triterpenoids from the fresh leaves of Psidium guajava. Planta Med. 2002;68(12):1149-1152. [Content Brief]

[2]. Jing-Ru WANG, et al. Effects of guavenoic acid on protection against oxidative damage in INS-1 Cells and its mechanisms. Chinese Pharmaceutical Journal ; (24): 233-238, 2015.

[3]. Kaihe YE, et al. Promoting effects of Guavenoic acid (GA)on proliferation,insulin synthesis and secretion in INS-1 cells and their mechanism. Chinese Pharmacological Bulletin ; (12): 1681-1687, 2014.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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