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PG490

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By Targets:	Apoptosis (5) Drug Derivative (1) Environmental Pollutants (1) IFNAR (2) Interleukin Related (2) Isotope-Labeled Compounds (1) NF-κB (5) Reference Standards (1) TGF-β Receptor (2) TNF Receptor (2)
By Research Areas:	Cancer (4) Inflammation/Immunology (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-32735

Triptolide 65+ Cited Publications PG490	Environmental Pollutants NF-κB Apoptosis	Cancer
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-16363

Omtriptolide PG 490-88	Apoptosis TGF-β Receptor NF-κB Interleukin Related IFNAR TNF Receptor	Inflammation/Immunology
Omtriptolide (PG490-88) is a derivative proagent of triptolide purified from the Chinese herb.

HY-32735R

Triptolide (Standard) PG490 (Standard)	Reference Standards NF-κB Apoptosis	Cancer
Triptolide (Standard) is the analytical standard of Triptolide. This product is intended for research and analytical applications. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-32735S

Triptolide-d3 PG490-d₃	Isotope-Labeled Compounds NF-κB Apoptosis	Cancer
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-32735C

(14R)-Triptolide (14R)-PG490	Drug Derivative	Cancer
(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC₅₀ of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer .

HY-16362

Omtriptolide sodium PG 490-88Na	Apoptosis TGF-β Receptor NF-κB Interleukin Related IFNAR TNF Receptor	Inflammation/Immunology
Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide (HY-32735). Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-32735

Triptolide 65+ Cited Publications PG490	Structural Classification Classification of Application Fields Anti-aging Celastraceae Tripterygium wilfordii Hook. f. Plants Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Source Classification Cancer	Environmental Pollutants NF-κB Apoptosis
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

HY-32735R

Triptolide (Standard) PG490 (Standard)	Structural Classification Terpenoids Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants Source Classification	Reference Standards NF-κB Apoptosis
Triptolide (Standard) is the analytical standard of Triptolide. This product is intended for research and analytical applications. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

Cat. No.	Product Name	Chemical Structure

HY-32735S

Triptolide-d3
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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PG490

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products