2. Others
  3. Drug Derivative
  4. (14R)-Triptolide

(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC50 of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer.

For research use only. We do not sell to patients.

(14R)-Triptolide

(14R)-Triptolide Chemical Structure

CAS No. : 144539-79-7

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of (14R)-Triptolide:

(14R)-Triptolide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC50 of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.059 μg/mL
Compound: 11
Cytotoxicity against human A549 lung tumor cells
Cytotoxicity against human A549 lung tumor cells
[PMID: 16455242]
A549 IC50
59 ng/mL
Compound: 1b, 14-epi-triptolide
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
[PMID: 18321701]
HT-29 IC50
0.0091 μg/mL
Compound: 11
Cytotoxicity against human HT29 colon tumor cells
Cytotoxicity against human HT29 colon tumor cells
[PMID: 16455242]
HT-29 IC50
9.1 ng/mL
Compound: 1b, 14-epi-triptolide
Cytotoxicity against human HT29 cells
Cytotoxicity against human HT29 cells
[PMID: 18321701]
MDA-MB-468 IC50
1.32 μM
Compound: 2
Cytotoxicity against human MDA-MB-468 cells by SRB assay
Cytotoxicity against human MDA-MB-468 cells by SRB assay
[PMID: 19637874]
PC-3 IC50
1.6 μM
Compound: 2
Cytotoxicity against human PC3 cells by SRB assay
Cytotoxicity against human PC3 cells by SRB assay
[PMID: 19637874]
PC-3 IC50
1320 nM
Compound: 2
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
[PMID: 24378709]
SK-OV-3 IC50
0.79 μM
Compound: 2
Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
[PMID: 19637874]
SK-OV-3 IC50
790 nM
Compound: 2
Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
[PMID: 24378709]
Molecular Weight

360.40

Formula

C20H24O6
CAS No.
SMILES

C[C@@]12[C@@]34[C@]5([C@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)C)O)[C@@](C[C@@]1([H])C7=C(C(OC7)=O)CC2)([H])O5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(14R)-Triptolide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(14R)-Triptolide144539-79-7(14R)-PG490Drug DerivativeDrug derivativeInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(14R)-Triptolide
Cat. No.:
HY-32735C
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.