(14R)-Triptolide
(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC50 of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 144539-79-7
- Formula: C20H24O6
- Molecular Weight:360.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.059 μg/mL
Compound: 11
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Cytotoxicity against human A549 lung tumor cells
Cytotoxicity against human A549 lung tumor cells
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[PMID: 16455242] |
| A549 | IC50 |
59 ng/mL
Compound: 1b, 14-epi-triptolide
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 18321701] |
| HT-29 | IC50 |
0.0091 μg/mL
Compound: 11
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Cytotoxicity against human HT29 colon tumor cells
Cytotoxicity against human HT29 colon tumor cells
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[PMID: 16455242] |
| HT-29 | IC50 |
9.1 ng/mL
Compound: 1b, 14-epi-triptolide
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Cytotoxicity against human HT29 cells
Cytotoxicity against human HT29 cells
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[PMID: 18321701] |
| MDA-MB-468 | IC50 |
1.32 μM
Compound: 2
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Cytotoxicity against human MDA-MB-468 cells by SRB assay
Cytotoxicity against human MDA-MB-468 cells by SRB assay
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[PMID: 19637874] |
| PC-3 | IC50 |
1.6 μM
Compound: 2
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Cytotoxicity against human PC3 cells by SRB assay
Cytotoxicity against human PC3 cells by SRB assay
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[PMID: 19637874] |
| PC-3 | IC50 |
1320 nM
Compound: 2
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Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
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[PMID: 24378709] |
| SK-OV-3 | IC50 |
0.79 μM
Compound: 2
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Cytotoxicity against human SKOV3 cells by SRB assay
Cytotoxicity against human SKOV3 cells by SRB assay
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[PMID: 19637874] |
| SK-OV-3 | IC50 |
790 nM
Compound: 2
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Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
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[PMID: 24378709] |
Chemical Information
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CAS No. 144539-79-7
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Molecular Weight 360.40
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Formula C20H24O6
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SMILES
C[C@@]12[C@@]34[C@]5([C@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)C)O)[C@@](C[C@@]1([H])C7=C(C(OC7)=O)CC2)([H])O5
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Synonyms
(14R)-PG490
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(14R)-Triptolide Related Classifications
HY-32735C Related Classifications
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