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Results for "

PSD

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

12

Peptides

3

Recombinant Proteins

7

Isotope-Labeled Compounds

12

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P0117
    Tat-NR2B9c
    5+ Cited Publications

    Tat-NR2Bct; NA-1

    iGluR NO Synthase Neurological Disease
    Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
    Tat-NR2B9c
  • HY-100456
    ZL006
    2 Publications Verification

    iGluR Neurological Disease
    ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
    ZL006
  • HY-100457
    IC87201
    2 Publications Verification

    iGluR Neurological Disease
    IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
    IC87201
  • HY-164288

    TDI-006570

    Cyclic GMP-AMP Synthase STING Neurological Disease Inflammation/Immunology
    TDI-6570 (TDI-006570) is a blood-brain barrier-permeable, orally active cGAS inhibitor with an IC50 of 1.64 μM. TDI-6570 exhibits high gastrointestinal absorption and a long brain half-life in mice, and shows no toxicity to primary neurons. By inhibiting the cGAS-STING-IFN signaling pathway, TDI-6570 reduces STING levels and the activation of TBK1, blocks double-stranded DNA-induced cGAS activation and downstream interferon-stimulated gene expression, thereby reducing tau protein spread and improving synaptic loss. TDI-6570 reverses memory deficits, increases the amplitude of long-term potentiation, enhances the MEF2C transcriptional network, restores PSD-95 and vGAT punctate structures, and significantly improves cognitive resilience. TDI-6570 can be applied to the research of Alzheimer's disease, Parkinson's disease, systemic lupus erythematosus, as well as various central nervous system and autoimmune diseases .
    TDI-6570
  • HY-W009118

    Amino Acid Derivatives Others
    Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .
    Fmoc-5-Ava-OH
  • HY-P0117A
    Tat-NR2B9c TFA
    5+ Cited Publications

    Tat-NR2Bct TFA; NA-1 TFA

    iGluR NO Synthase Neurological Disease
    Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .
    Tat-NR2B9c TFA
  • HY-117772

    iGluR Metabolic Disease Inflammation/Immunology
    FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects .
    FSC231
  • HY-P1195

    iGluR Neurological Disease
    PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .
    PDZ1 Domain inhibitor peptide
  • HY-P11263

    iGluR Neurological Disease
    AVLX-144 is a highly potent inhibitor of postsynaptic density protein 95 (PSD-95). AVLX-144 can be used as a template to develop imaging probes for postsynaptic density (PSD) molecules, and can be labeled with fluorine-18 (¹⁸F) or tritium (³H) to visualize PSD-95 in vivo. AVLX-144 can be utilized for the study of Parkinson's disease .
    AVLX-144
  • HY-146885S
    16:0-18:1 PS-d31 sodium
    1 Publications Verification

    Isotope-Labeled Compounds Others
    16:0-18:1 PS-d31 (sodium) is deuterium labeled 16:0-18:1 PS (sodium).
    16:0-18:1 PS-d31 sodium
  • HY-176866

    HDAC Neurological Disease
    Rodin-A is an orally active, brain-penetrant and selective histone deacetylase (HDAC)-co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 1.80 μM for the CoREST complex, 0.15 μM for HDAC1, and 0.43 μM for HDAC2. Rodin-A increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-A is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease .
    Rodin-A
  • HY-123566

    RO 3202904

    mAChR Metabolic Disease
    PSD-506 (RO 3202904) is a muscarinic M2/M3 antagonist. PSD-506 has the potential to be used in studies of bladder overactivity and urinary incontinence .
    PSD-506
  • HY-RS24698

    Small Interfering RNA (siRNA) Others

    Psd Rat Pre-designed siRNA Set A contains three designed siRNAs for Psd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Psd Rat Pre-designed siRNA Set A
    Psd Rat Pre-designed siRNA Set A
  • HY-RS11272

    Small Interfering RNA (siRNA) Others

    PSD Human Pre-designed siRNA Set A contains three designed siRNAs for PSD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PSD Human Pre-designed siRNA Set A
    PSD Human Pre-designed siRNA Set A
  • HY-RS11273

    Small Interfering RNA (siRNA) Others

    PSD2 Human Pre-designed siRNA Set A contains three designed siRNAs for PSD2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PSD2 Human Pre-designed siRNA Set A
    PSD2 Human Pre-designed siRNA Set A
  • HY-RS11274

    Small Interfering RNA (siRNA) Others

    PSD3 Human Pre-designed siRNA Set A contains three designed siRNAs for PSD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PSD3 Human Pre-designed siRNA Set A
    PSD3 Human Pre-designed siRNA Set A
  • HY-RS11275

    Small Interfering RNA (siRNA) Others

    PSD4 Human Pre-designed siRNA Set A contains three designed siRNAs for PSD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PSD4 Human Pre-designed siRNA Set A
    PSD4 Human Pre-designed siRNA Set A
  • HY-P2307

    iGluR NO Synthase Neurological Disease
    Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
    Tat-NR2Baa
  • HY-P2307A

    iGluR NO Synthase Neurological Disease
    Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .
    Tat-NR2Baa TFA
  • HY-P1195A

    iGluR Neurological Disease
    PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain .
    PDZ1 Domain inhibitor peptide TFA
  • HY-RS10573

    Small Interfering RNA (siRNA) Others

    PISD Human Pre-designed siRNA Set A contains three designed siRNAs for PISD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PISD Human Pre-designed siRNA Set A
    PISD Human Pre-designed siRNA Set A
  • HY-P10212

    UCCB01-125

    iGluR Neurological Disease
    AVLX-125 (UCCB01-125) is a PSD-95 and PDZ domain inhibitor with Kd value of 10 nM. AVLX-125 can be used in the study of inflammatory pain .
    AVLX-125
  • HY-155355

    iGluR Neurological Disease
    LY836 is an orally active neuroprotective agent. LY836 significantly blocks PSD95-nNOS association in cortical neurons. LY836 can be used in study ischemic stroke .
    LY836
  • HY-P10401

    Apoptosis iGluR Cardiovascular Disease Neurological Disease
    TAT-GluR6-9c is a GluR6-PSD95 interaction blocker. By regulating the GluR6 mediated signaling pathway, TAT-GluR6-9c inhibits the activation of JNK and phosphorylation of c-Jun, reduces the expression of Fas L and thus reduces the occurrence of apoptosis. TAT-GluR6-9c can be used to study cerebral ischemia and neuroprotective strategies .
    TAT-GluR6-9c
  • HY-143675S

    Isotope-Labeled Compounds Others
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9 is the deuterium labeled 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS .
    1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9
  • HY-167592S

    1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine sodium

    Isotope-Labeled Compounds Others
    17:0-20:3 PS-d5 (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .
    17:0-20:3 PS-d5
  • HY-100458

    NO Synthase Neurological Disease
    SCR-4026 is a neuroprotective agent with blood-brain barrier penetration ability. SCR-4026 exerts neuroprotective effects by disrupting the interaction between neuronal nNOS and PSD9, with an IC50 of 6.3 μM. SCR-4026 alleviates N-methyl-D-aspartate (NMDA)-induced excitotoxic damage in primary cortical neurons, and also protects neurons in the oxygen-glucose deprivation (OGD) model. SCR-4026 can reduce the cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model. SCR-4026 can be used for the study of stroke .
    SCR-4026
  • HY-175824

    iGluR NO Synthase Apoptosis Reactive Oxygen Species (ROS) Neurological Disease
    PSD-95/nNOS PPI-IN-1 is a inhibitor targeting the PSD-95/nNOS interaction with potential blood-brain barrier penetration. PSD-95/nNOS PPI-IN-1 binds to the PSD-95 PDZ2 domain with high affinity (Ki = 19.45 μM). PSD-95/nNOS PPI-IN-1 inhibits glutamate-induced excitotoxicity by reducing intracellular ROS levels and inhibiting apoptosis. PSD-95/nNOS PPI-IN-1 significantly reduces cerebral infarct volume in rat tMCAO models. PSD-95/nNOS PPI-IN-1 can be used for the study of acute ischemic stroke .
    PSD-95/nNOS PPI-IN-1
  • HY-176867

    HDAC Neurological Disease
    Rodin-B is a selective histone deacetylase (HDAC)-co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 0.50 μM for the CoREST complex, 0.27 μM for HDAC1, and 0.28 μM for HDAC2. Rodin-B increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-B is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease .
    Rodin-B
  • HY-RS18221

    Small Interfering RNA (siRNA) Others

    Psd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Psd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Psd Mouse Pre-designed siRNA Set A
    Psd Mouse Pre-designed siRNA Set A
  • HY-100457R

    iGluR Reference Standards Neurological Disease
    IC87201 (Standard) is the analytical standard of IC87201 (HY-100457). This product is intended for research and analytical applications. IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
    IC87201 (Standard)
  • HY-178754S

    Isotope-Labeled Compounds Others
    12-Dipalmitoyl-sn-glycero-3-PS-d3 ammonium is the deuterium labeled 12-Dipalmitoyl-sn-glycero-3-PS ammonium.
    12-Dipalmitoyl-sn-glycero-3-PS-d3 ammonium
  • HY-100456R

    iGluR Reference Standards Neurological Disease
    ZL006 (Standard) is the analytical standard of ZL006 (HY-100456). This product is intended for research and analytical applications. ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
    ZL006 (Standard)
  • HY-184078

    Drug Derivative Indoleamine 2,3-Dioxygenase (IDO) Tau Protein iGluR Neurological Disease
    8-F-2-(Me-Pip-Me)-Tryptanthrin is a tryptanthrin derivative with blood-brain barrier penetration. 8-F-2-(Me-Pip-Me)-Tryptanthrin protects neurons from Aβ-induced apoptosis, inhibits Aβ-induced Tau protein hyperphosphorylation and neuronal synaptic damage, and improves learning and memory abilities in Alzheimer's disease mice. 8-F-2-(Me-Pip-Me)-Tryptanthrin can be used for the research of nervous system diseases, including diseases related to abnormal Tau protein phosphorylation and abnormal PSD-95 function .
    8-F-2-(Me-Pip-Me)-Tryptanthrin
  • HY-178737S

    18:2 PS-d3 ammonium

    Isotope-Labeled Compounds Others
    1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine-d3 ammonium (18:2 PS-d3 ammonium) is the deuterium labeled 1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine ammonium.
    1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine-d3 ammonium
  • HY-145539SA

    Isotope-Labeled Compounds Others
    1,2-Dipalmitoyl-sn-glycero-3-PS-d62 ammonium is the deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-PS ammonium. 1,2-Dipalmitoyl-sn-glycero-3-PS is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS is used for the preparation of phospholipid bilayers.
    1,2-Dipalmitoyl-sn-glycero-3-PS-d62 ammonium
  • HY-145539S

    Isotope-Labeled Compounds Liposome Others
    1,2-Dipalmitoyl-sn-glycero-3-PS-d62 sodium is deuterium labeled 1,2-Dipalmitoyl-sn-glycero-3-PS sodium (HY-145539). 1,2-Dipalmitoyl-sn-glycero-3-PS sodium is a phosphatidylserine phospholipid. 1,2-Dipalmitoyl-sn-glycero-3-PS sodium is used for the preparation of phospholipid bilayers .
    1,2-Dipalmitoyl-sn-glycero-3-PS-d62 sodium salt

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