2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. NYX-2925

NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders.

For research use only. We do not sell to patients.

NYX-2925 Chemical Structure

NYX-2925 Chemical Structure

CAS No. : 2012536-16-0

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1 mg USD 350 In-stock
5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2580 In-stock
50 mg USD 4000 In-stock
100 mg USD 6400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders[1][2].

IC50 & Target[1][2]

NMDA Receptor

 

Clinical Trial
Molecular Weight

297.35

Formula

C14H23N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)C(N1[C@@]2(CCC1)C(N(C2)[C@H](C(N)=O)[C@H](O)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (336.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3630 mL 16.8152 mL 33.6304 mL
5 mM 0.6726 mL 3.3630 mL 6.7261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3630 mL 16.8152 mL 33.6304 mL 84.0760 mL
5 mM 0.6726 mL 3.3630 mL 6.7261 mL 16.8152 mL
10 mM 0.3363 mL 1.6815 mL 3.3630 mL 8.4076 mL
15 mM 0.2242 mL 1.1210 mL 2.2420 mL 5.6051 mL
20 mM 0.1682 mL 0.8408 mL 1.6815 mL 4.2038 mL
25 mM 0.1345 mL 0.6726 mL 1.3452 mL 3.3630 mL
30 mM 0.1121 mL 0.5605 mL 1.1210 mL 2.8025 mL
40 mM 0.0841 mL 0.4204 mL 0.8408 mL 2.1019 mL
50 mM 0.0673 mL 0.3363 mL 0.6726 mL 1.6815 mL
60 mM 0.0561 mL 0.2803 mL 0.5605 mL 1.4013 mL
80 mM 0.0420 mL 0.2102 mL 0.4204 mL 1.0510 mL
100 mM 0.0336 mL 0.1682 mL 0.3363 mL 0.8408 mL
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NYX-2925 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NYX-29252012536-16-0NYX2925NYX 2925iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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