2012536-16-0
Chemical Structure
NYX-2925
- CAS No.: 2012536-16-0
- Formula:C14H23N3O4
- Molecular Weight:297.35
IUPAC Name: (2S,3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide
InChIKey: NFXPEHLDVKVVKA-ISTVAULSSA-N
SMILES: CC(C)C(N1[C@@]2(CCC1)C(N(C2)[C@H](C(N)=O)[C@H](O)C)=O)=O
Biological Activity: NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders[1][2].
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NYX-2925 | 98.98% | NYX-2925 is an orally active NMDAR modulator. NYX-2925 restores levels of activated Src and Src phosphorylation sites on GluN2A and GluN2B in the mPFC. NYX-2925 shows no effect on CAMKII, and any addictive or sedative/ataxic side effects. NYX-2925 can be used for research of a variety of NMDA receptor-mediated central nervous system disorders. | ||||||||||||||||||||
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- [1]. Zeng Y, et al. New advances in small molecule drugs targeting NMDA receptors. Acta pharmacologica Sinica. 2026 Jan;47(1):3-21.
- [2]. Morrison G, et al. The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC. Neurobiology of pain (Cambridge, Mass.). 2020;7:100039. [Content Brief]
Keywords
