FSC231

Cat. No.: HY-117772: FAQs
Data Sheet Handling Instructions

Molarity Calculator

FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects.

For research use only. We do not sell to patients.

FSC231 Chemical Structure

CAS No. : 1215849-96-9

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects^[1].

IC₅₀ & Target

PICK1^[1].

In Vitro

FSC231 (50 μM) blocks binding between GluR2 and PICK1 in COS7 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FSC231 (78.40 μg/kg in total, daily, seven times, i.p., 3 h before Paclitaxel) alleviates the Paclitaxel (HY-B0015)‐induced neuralgia of rats^[1].
FSC231 (39.2μg/kg/day, i.p., for 4 weeks) inhibits the development of diabetic cardiomyopathy in rats by inhibiting ROS generation and apoptosis partly via PICK1/eNOS/cGMP pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Paclitaxel (HY-B0015)‐induced neuralgia of rats^[1]
Dosage:	78.40 μg/kg in total
Administration:	i.p., daily, seven times, completed at 3 h before Paclitaxel
Result:	Reversed the changes of inflammatory cytokines (IL‐6, TNF‐α and IL‐10). Inhibited the phosphorylation levels of GSK‐3β and ERK1/2.

Molecular Weight

313.14

Formula

C₁₃H₁₀Cl₂N₂O₃

CAS No.

1215849-96-9

SMILES

O=C(OCC)NC(/C(C#N)=C/C1=CC=C(Cl)C(Cl)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. FSC231 alleviates paclitaxel-induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK-3β and ERK1/2. Brain Behav. 2021 Nov;11(11):e2380. [Content Brief]

[2]. Thorsen TS, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. [Content Brief]

[3]. Cai Fei, et al. GW27-e1146 PICK1 inhibition restores myocardial injury by suppressing reactive oxygen species generation and apoptosis in diabetic rats. J Am Coll Cardiol. 2016 Oct, 68 (16_Supplement) C67.

FSC231 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSC2311215849-96-9FSC 231FSC-231Othersneuralgiadiabetic cardiomyopathyCOS7Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks