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Peroxiredoxin 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (1) Fungal (1) Interleukin Related (1) Reactive Oxygen Species (ROS) (1) ROS Kinase (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-170488

CM-728	ROS Kinase Bacterial	Infection Cancer
CM-728 is a oxazepine-naphthoquinone that has cytotoxic and bactericidal effect. CM-728 is a human *peroxiredoxin-1* inhibitor. CM-728 is an oxidative stressor that affects mitochondrial function .

HY-W671129

Frenolicin B	Antibiotic Fungal	Infection
Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC₅₀ of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits *Peroxiredoxin 1* via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria .

HY-158368

PRDX1-IN-2	Apoptosis Reactive Oxygen Species (ROS)	Cancer
PRDX1-IN-2 (compound 15) is a selective inhibitor of the antioxidant enzyme Peroxiredoxin 1 (PRDX1) (IC₅₀=0.35 μM). PRDX1-IN-2 decreases the mitochondria membrane potential of SW620 cells, probably due to ROS induced by PRDX1 inhibition, leading to cell apoptosis. PRDX1-IN-2 can be used for colorectal cancer research .

HY-182308

LC-PDA-01	Interleukin Related TNF Receptor	Inflammation/Immunology
LC-PDA-01 is a selective peroxiredoxin 1 (PRDX1) activator with an EC₅₀ of 111.8 nM and a human K_D of 123.2 nM. LC-PDA-01 inhibits the expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α. LC-PDA-01 can be used in antioxidant/anti-inflammatory research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W671129

Frenolicin B	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Frenolicin B is a covalent enzyme inhibitor and an orally active antiparasitic agent, with an IC₅₀ of 0.2 μM against human Prx1. Frenolicin B selectively inhibits Glutaredoxin 3 via covalent modification of the active-site cysteines Cys159/Cys261. Frenolicin B selectively inhibits *Peroxiredoxin 1* via covalent modification of the active-site cysteines Cys83/Cys173. Frenolicin B can be used in research related to colon cancer, breast cancer, lung cancer and malaria .

Species:	Human (3) Mouse (2)
Tag:	His (5)
Source:	P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73713

	PRDX1 Protein, Mouse (His) Peroxiredoxin-1; OSF-3; PRDX1; Msp23; Paga; Tdpx2	Mouse	E. coli
	The PRDX1 protein is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols.Its key role in cellular protection against oxidative stress includes detoxifying superoxide and acting as a sensor of hydrogen peroxide-mediated signaling events.PRDX1 Protein, Mouse (His) is the recombinant mouse-derived PRDX1 protein, expressed by E.coli , with C-His labeled tag.

HY-P71231

	*PRDX1/Peroxiredoxin-1* Protein, Human (His)** 2 Publications Verification Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; PAGA; PAGB; TDPX2	Human	E. coli
	Peroxiredoxin-1 (PRDX1) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides and plays a crucial role in cellular protection against oxidative stress. It detoxifies peroxide and senses hydrogen peroxide-mediated signaling events. PRDX1/Peroxiredoxin-1 Protein, Human (His) is the recombinant human-derived PRDX1 protein, expressed by E. coli , with C-6His, N-6His labeled tag.

HY-P790076

	PRDX6 Protein, Mouse (His) Peroxiredoxin-6; 1-Cys Peroxiredoxin (1-Cys PRX); Aop2, Ltw4, Prdx5	Mouse	E. coli
	PRDX6 Protein, Mouse (His) is the recombinant mouse-derived PRDX6, expressed by E. coli , with C-6*His labeled tag. ,

HY-P790010

	*PRDX1/Peroxiredoxin-1* Protein, Human (P. pastoris, His)** PRDX1; PAG; OSF3; Paga; PrxI; TDX2; TPxA; prx1; MSP23	Human	P. pastoris
	Peroxiredoxin-1 (PRDX1) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides and plays a crucial role in cellular protection against oxidative stress. It detoxifies peroxide and senses hydrogen peroxide-mediated signaling events. PRDX1/Peroxiredoxin-1 Protein, Human (P. pastoris, His) is the recombinant human-derived Peroxiredoxin-1 protein, expressed by P. pastoris , with C-6*His labeled tag.

HY-P71145

	PRDX6 Protein, Human (His) Peroxiredoxin-6; 1-Cys Peroxiredoxin; 1-Cys PRX; 24 kDa Protein; Acidic Calcium-Independent Phospholipase A2; aiPLA2; Antioxidant Protein 2; Liver 2D PAGE Spot 40; Non-Selenium Glutathione Peroxidase; NSGPx; Red Blood Cells Page Spot 12; PRDX6; AOP2; KIAA0106	Human	E. coli
	The PRDX6 protein is a thiol-specific peroxidase that plays a crucial role in cellular defense against oxidative stress. It catalyzes the reduction of hydrogen peroxide and various organic hydroperoxides to water and alcohols. PRDX6 Protein, Human (His) is the recombinant human-derived PRDX6 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (4) ICC/IF (4) IP (1) IHC-F (2) WB (4) ELISA (1)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80782

	Peroxiredoxin 1 Antibody (YA692) PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Peroxiredoxin 1 Antibody (YA692) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Peroxiredoxin 1.

HY-P85678

	Peroxiredoxin 1 Antibody (YA5370) PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Peroxiredoxin 1 Antibody (YA5370) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Peroxiredoxin 1.

HY-P86506

	Peroxiredoxin 1 Antibody (YA6198) PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Peroxiredoxin 1 Antibody (YA6198) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Peroxiredoxin 1.

HY-P80782A

	Peroxiredoxin 1 Antibody (YA692)(PBS only) PRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Peroxiredoxin 1 Antibody (YA692) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Peroxiredoxin 1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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