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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
Piezo1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "Piezo1" in MCE Product Catalog:
126
126 Publications Verification
Cat. No.: HY-P1410
CAS No.: 1209500-46-8
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
126
126 Publications Verification
Cat. No.: HY-P1410A
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
113
113 Cited Publications
Cat. No.: HY-18723
CAS No.: 448947-81-7
Target:
Research Areas:
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] .
16
16 Cited Publications
Target:
Research Areas:
Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca 2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research [1].
2
2 Cited Publications
Target:
Research Areas:
Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM [1].
1
1 Cited Publications
Cat. No.: HY-162501
CAS No.: 3041134-13-5
Target:
Research Areas:
Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 μM. Yaddle1 can significantly trigger Ca 2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants [1].
Cat. No.: HY-175416
CAS No.: 3081450-95-2
Synonyms: KC289
Target:
Research Areas:
Yoda2 (KC289), the potassium salt of Yoda1 (HY-18723), is a PIEZO1 agonist with an EC50 of 150 nM. Yoda2 evokes Ca 2+ elevation and NO-dependent relaxation. Yoda2 induces relaxation in mouse arterial and cavernous tissues. Yoda2 inhibits glucocorticoid-induced osteoclast formation and bone resorptive activity, reverses glucocorticoid-induced bone density loss and architectural deterioration, and does not induce medication-related osteonecrosis of the jaw in mice. Yoda2 can be used for the researches of hypertension and osteoporosis [1] .
Cat. No.: HY-RS10483
Target:
Research Areas:
PIEZO1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIEZO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17433
Target:
Research Areas:
Piezo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Piezo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-165607S
CAS No.: 3058199-58-6
Cat. No.: HY-169332
CAS No.: 3058199-62-2
Cat. No.: HY-181743
CAS No.: 3124796-49-9
Research Areas:
Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 releases Jedi2 in mice. Piezo1 agonist 2 can be used for the research of neurodegenerative diseases [1].
Cat. No.: HY-RS23888
Target:
Research Areas:
Piezo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Piezo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-181467
CAS No.: 3081200-39-4
Target:
Research Areas:
KC159 is a Yoda1 analog, as well as an agonist of Piezo1 and Piezo2. KC159 can be used for cultured adipocyte production [1].
Cat. No.: HY-P86875
Synonyms: DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 Piezo1 Protein FAM38A DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 Piezo1 Protein FAM38A Protein FAM38B Protein Piezo1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
