3058199-62-2
Chemical Structure
Piezo1 agonist 1-d2
- CAS No.: 3058199-62-2
- Formula:C16H13D2Cl2N5OS2
- Molecular Weight:430.37
InChIKey: XPQKPOPHNKADDB-MWRPJYTPSA-N
SMILES: ClC1=C(C(Cl)=CC=C1)C([2H])(SC2=NN=C(S2)C3=CN=C(C=N3)NC[C@@H](C)O)[2H]
Biological Activity: Piezo1 agonist 1-d2 is a Piezo1 agonist and osteogenesis promoter with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates Piezo1 and induces calcium ion influx in mesenchymal stem cells. Piezo1 agonist 1-d2 activates the Erk signaling pathway and promotes osteogenesis of mesenchymal stem cells. Piezo1 agonist 1-d2 alleviates disuse osteoporosis in a hindlimb unloading rat model. Piezo1 agonist 1-d2 can be used for research on osteoporosis[1].
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Piezo1 agonist 1-d2 | Piezo1 agonist 1-d2 is a Piezo1 agonist and osteogenesis promoter with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates Piezo1 and induces calcium ion influx in mesenchymal stem cells. Piezo1 agonist 1-d2 activates the Erk signaling pathway and promotes osteogenesis of mesenchymal stem cells. Piezo1 agonist 1-d2 alleviates disuse osteoporosis in a hindlimb unloading rat model. Piezo1 agonist 1-d2 can be used for research on osteoporosis. | |||||||||||||||||||||
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