3 Results for "

Pomalidomide-C12-NH2

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Pomalidomide-C12-NH2" in MCE Product Catalog:

Cat. No.: HY-178076
CAS No.: 2414414-60-9
Research Areas:  

Others

Pomalidomide-C12-NH2 is a conjugate of an E3 ligase and a linker, which can be used for the synthesis of PROTACs, such as PROTAC KRAS G12C degrader-1 (HY-139186) .
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Cat. No.: HY-145615
CAS No.: 2862774-02-3
Purity:  97.09%
Research Areas:  

Cancer

Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a Cereblon-based KRAS G12C degrader .
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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