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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Quinone Derivative
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Quinone Derivative" in MCE Product Catalog:
1
1 Cited Publications
Research Areas:
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .
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PQQ-trimethylester (PQQ-TME) is a synthetic compound that is a trimethylester derivative of pyrroloquinoline quinone (PQQ). PQQ-trimethylester has twice the blood-brain barrier permeability of PQQ (HY-100196) in vitro. In addition, PQQ-trimethylester shows strong inhibitory activity against α-synuclein, amyloid β1-42 (Aβ1-42) and prion protein fibrillation. PQQ-trimethylester can be used in the study of neurodegenerative diseases .
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1 Cited Publications
Cat. No.: HY-W176199
CAS No.: 3421-08-7
Research Areas:
DPPD-Q is a quinone derivative of p-phenylenediamine antioxidants and an analog of DTPD-Q (HY-163650). DPPD-Q is identified as a major sewage treatment plant effluent .
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1 Cited Publications
Cat. No.: HY-W007671
CAS No.: 1080-06-4
Category:
Monophenols Other Diseases Phenols Amino acids Endogenous metabolite Disease Research Fields
Target:
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1 Cited Publications
Cat. No.: HY-W012228
CAS No.: 3417-91-2
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H-Tyr-OMe.HCl is an amino acid derivative and also a coordinating ligand for Cu II ions. H-Tyr-OMe.HCl can serve as a surface functionalization reagent for carbon dots, and is used to prepare fluorescent probes for biothiol sensing. H-Tyr-OMe.HCl is oxidized to quinone under the catalysis of Tyrosinase via its phenolic hydroxyl group, which quenches the fluorescence of carbon dots. H-Tyr-OMe.HCl contains potential coordination sites, including carboxyl, amino and phenolic hydroxyl groups .
Cat. No.: HY-15932
CAS No.: 82692-93-1
Synonyms: TOOS sodium salt
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EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research .
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EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis .
Cat. No.: HY-176151
CAS No.: 3121970-31-5
Synonyms: HPPD-Quinone
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HPPD-Q (HPPD-quinone) is a substituted p-phenylenediamine quinone and derivative of 6-PPD-Q.
Cat. No.: HY-N11789
CAS No.: 100205-29-6
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Cat. No.: HY-CE01425
Synonyms: 6-Hydroxydopa Quinone-coenzyme A
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6-Hydroxydopa-quinone-CoA (6-Hydroxydopa quinone-coenzyme A) is a coenzyme A derivative .
Cat. No.: HY-169493
CAS No.: 2952779-34-7
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OPPD-Q is a p-phenylenediamine-quinone (PPD-Q) and an oxidized derivative of the aromatic amine antioxidant OPPD.
Cat. No.: HY-W007671R
CAS No.: 1080-06-4
Category:
CCPD-Q (CCPD-Quinone) is a quinone derivative of phenylenediamine-based tire wear compounds, as well as a Urease inhibitor against Helicobacter pylori, with an IC50 value of 41.50 μM. CCPD-Q can be used in studies related to Helicobacter pylori infection .
Cat. No.: HY-N20681
CAS No.: 168146-21-2
Category:
Monophenols Rutaceae Phenols Tetradium glabrifolium (Champion ex Bentham) T. G. Hartley Plants
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Cat. No.: HY-N17587
CAS No.: 625434-15-3
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Cat. No.: HY-L021M
5,073 compounds
From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research.
MCE provides a unique collection of 5,073 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
