1147883-03-1
Chemical Structure
EPI-589
- CAS No.: 1147883-03-1
- Formula:C14H19NO4
- Molecular Weight:265.30
IUPAC Name: (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
InChIKey: BAANPNDZFYBQIB-CQSZACIVSA-N
SMILES: CC1=C(C(C(CC[C@@](O)(C(N)=O)C)=C(C1=O)C)=O)C
Biological Activity: EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research[1][2][3][4].
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EPI-589 | 99.34% | EPI-589, a quinone derivative, is a safe and well tolerated oxidoreductase enzyme inhibitor and a free radical scavenger, with blood-brain barrier permeable and orally available. EPI-589 is a redox-active neuroprotectant that effectively delays the symptoms of motor neuron disease in wobbler mice. EPI-589 can be used in amyotrophic lateral sclerosis (ALS) research. | ||||||||||||||||||||
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- [1]. Ng N, et al. Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging. Neural Regen Res. 2025 Mar 1;20(3):794-796. [Content Brief]
- [2]. Matsumoto Y, et al. EPI-589, a redox-active neuroprotectant, potently protects cultured cells from oxidative stress and alleviates symptomatic and pathological progression of motor neuron disease in the wobbler mouse[J]. bioRxiv, 2022: 2022.03. 13.484182.
- [3]. Martinez A, et al. Drugs in clinical development for the treatment of amyotrophic lateral sclerosis[J]. Expert opinion on investigational drugs, 2017, 26(4): 403-414.
- [4]. BioElectron’s EPI-589 Shows Positive Results in ALS Patients in Phase 2a Trial
Keywords
