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Results for "

RRM1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

5

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0527
    Pentagalloylglucose
    10+ Cited Publications

    Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

    		 JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) E1/E2/E3 Enzyme Neurological Disease Inflammation/Immunology Cancer
    Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities [1] .
    Pentagalloylglucose
  • HY-153898
    rTRD01

    		Amyloid-β Neurological Disease
    rTRD01 is an orally active, specific TDP-43 binder that targets the RRM1 and RRM2 domains of TDP-43. rTRD01 partially disrupts the interaction between TDP-43 and c9orf72 repeat RNA, but does not affect the binding of TDP-43 to canonical binding sequences. rTRD01 exhibits significant neuroprotective effects in zebrafish models, improves motor function and protects against paraquat (a widely used herbicide)-induced neurodegeneration, with no teratogenicity at high concentrations. rTRD01 is not a general antioxidant and cannot counteract Rotenone (HY-B1756)-induced neuronal death. rTRD01 can be used to study amyotrophic lateral sclerosis and other TDP-43 proteinopathies [1] .
    rTRD01
  • HY-153736
    NSC 194308

    		DNA/RNA Synthesis Cancer
    NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations [1].
    NSC 194308
  • HY-RS12285
    RRM1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RRM1 Human Pre-designed siRNA Set A contains three designed siRNAs for RRM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RRM1 Human Pre-designed siRNA Set A
    RRM1 Human Pre-designed siRNA Set A
  • HY-RS25122
    Rrm1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Rrm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rrm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rrm1 Rat Pre-designed siRNA Set A
    Rrm1 Rat Pre-designed siRNA Set A
  • HY-RS18637
    Rrm1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Rrm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rrm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rrm1 Mouse Pre-designed siRNA Set A
    Rrm1 Mouse Pre-designed siRNA Set A
  • HY-N0527R
    Pentagalloylglucose (Standard)

    Penta-O-galloyl-β-D-glucose (Standard); 1,2,3,4,6-Pentagalloyl glucose (Standard)

    		 Reference Standards JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology Cancer
    Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities [1] .
    Pentagalloylglucose (Standard)

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