RRM1 Protein, Human (sf9, His-GST)
RRM1 Protein, crucial for DNA synthesis, catalyzes the biosynthesis of deoxyribonucleotides from ribonucleotide precursors. Its enzymatic activity is essential, providing building blocks for accurate and efficient DNA replication. RRM1 Protein, Human (sf9, His-GST) is the recombinant human-derived RRM1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
RRM1 Protein, crucial for DNA synthesis, catalyzes the biosynthesis of deoxyribonucleotides from ribonucleotide precursors. Its enzymatic activity is essential, providing building blocks for accurate and efficient DNA replication. RRM1 Protein, Human (sf9, His-GST) is the recombinant human-derived RRM1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
Background
The RRM1 protein serves a crucial role in DNA synthesis by catalyzing the biosynthesis of deoxyribonucleotides from their corresponding ribonucleotide precursors. This enzymatic activity is essential for providing the necessary building blocks required for the intricate process of DNA replication, ensuring the accurate and efficient synthesis of new DNA strands.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-His;N-GST
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Accession
P23921 (M1-S792)
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Molecular Construction
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N-term
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His-GST
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RRM1 (M1-S792)
Accession # P23921 -
C-term
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Protein Length
Full Length
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Synonyms
RRM1; RR1; Ribonucleotide Reductase Catalytic Subunit M1; Ribonucleotide Reductase, R1 Subunit; Ribonucleoside-Diphosphate Reductase Large Subunit; Ribonucleoside-Diphosphate Reductase; Ribonucleoside-Diphosphate Reductase Subunit M1; PEOB6; Ribonucleotid
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AA Sequence
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
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Predicted Molecular Mass
117.9 kDa
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Molecular Weight
Approximately 98 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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