RRM1 - ribonucleotide reductase catalytic subunit M1 Gene

Also Known as R1; RR1; RIR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6240

About RRM1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,094,685-4,138,932 (from NCBI)

This gene has 14 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in skin (RPKM 18.5), lymph node (RPKM 18.3) and 25 other tissues.

Summary

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RRM1 Products (4)

mRNA	Protein	Name
NM_001033.5	NP_001024.1	ribonucleoside-diphosphate reductase large subunit isoform 1
NM_001318064.1	NP_001304993.1	ribonucleoside-diphosphate reductase large subunit isoform 2
NM_001318065.1	NP_001304994.1	ribonucleoside-diphosphate reductase large subunit isoform 3
NM_001330193.1	NP_001317122.1	ribonucleoside-diphosphate reductase large subunit isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17726094	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17726094	GOA
enables ribonucleoside-diphosphate reductase activity	IMP IMP: Inferred from mutant phenotype	21336276	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 2'-deoxyribonucleotide biosynthetic process	IDA IDA: Inferred from direct assay	16376858	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	11719458	GOA
involved in mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	17486094	GOA
involved in positive regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	11517226	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	24253041	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	10716435	GOA
involved in ribonucleoside diphosphate metabolic process	IDA IDA: Inferred from direct assay	16376858	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	18997010	GOA
part of ribonucleoside-diphosphate reductase complex	IPI IPI: Inferred from physical interaction	22632967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRM1 Protein Structure

ATP-cone

Ribonuc_red_lgN

Ribonuc_red_lgC

0
200
400
600
792 a.a.

Protein Preferred Names	Protein Names
ribonucleoside-diphosphate reductase large subunit	ribonucleoside-diphosphate reductase subunit M1

RRM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	Anti Tag CoIP	33961781
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	Anti Tag CoIP	28514442
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	GMS	21336276
Intra	RRM1	P23921	RRM2	Homo sapiens	P31350	GMS	17726094
Intra	RRM1	P23921	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	RRM1	P23921	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	RRM1	P23921	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	RRM1	P23921	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	28514442
Intra	RRM1	P23921	ARL5B	Homo sapiens	Q96KC2	Anti Tag CoIP	28514442
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	X-Ray Diffraction	21336276
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	Light Scattering	21336276
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	GMS	17726094
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	GMS	21336276
Intra	RRM1	P23921	RRM1	Homo sapiens	P23921	Y2H Array	25416956
Intra	RRM1	P23921	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	33961781
Intra	RRM1	P23921	ARL5B	Homo sapiens	Q96KC2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RRM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74591	RRM1 Protein, Human (sf9, His-GST)	P23921 (M1-S792)	≥ 95%, as determined by reducing SDS-PAGE.

RRM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82138	RRM1 Antibody (YA1883)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P82138A	RRM1 Antibody (YA1883)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P84202	RRM1 Antibody (YA3899)	WB, IHC-P, FC, ELISA	Human
HY-P84202A	RRM1 Antibody (YA3899)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P86475	RRM1 Antibody (YA6167)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
Retinitis Pigmentosa 7	Leber Congenital Amaurosis 18 RP7 Retinitis Pigmentosa 7, Digenic Form Retinitis Pigmentosa 7 And Digenic Form Retinitis Pigmentosa 7, Digenic LCA18 Retinitis Pigmentosa 7 Digenic
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0527	Pentagalloylglucose		99.57%	Unkown
HY-P5960	PTBP1-RNA-binding inhibitor P6 TFA		98.59%	Unkown
HY-153898	rTRD01	Ligand	99.10%	Unkown
HY-153736	NSC 194308		99.86%	Unkown
HY-RS12285	RRM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18637	Rrm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25122	Rrm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RRM1	VGNC	VGNC:34164
Rattus norvegicus	RRM1	RGD	RGD:1592569
Canis familiaris	RRM1	VGNC	VGNC:45760
Macaca mulatta	RRM1	VGNC	VGNC:76941
Mus musculus	RRM1	MGD	MGI:98180
Felis catus	RRM1	VGNC	VGNC:64775
Others	RRM1	NCBI