ARL5B - ADP ribosylation factor like GTPase 5B Gene

Also Known as ARL8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221079

About ARL5B

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:18,659,431-18,681,639 (from NCBI)

This gene has 1 transcript (splice variant), 200 orthologues and 30 paralogues. Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues.

Summary

ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the Ras superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

ARL5B Products (1)

mRNA Protein Name
NM_178815.5 NP_848930.1 ADP-ribosylation factor-like protein 5B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in protein localization to Golgi membrane IMP
IMP: Inferred from mutant phenotype
25795912 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL5B Protein Structure

Arf

Arf: ADP-ribosylation factor family (5 - 175)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 5B

  • ADP-ribosylation factor-like 5B

ARL5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARL5B Q96KC2 FNDC11 Homo sapiens Q9BVV2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00992 ARL5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARL5B VGNC VGNC:38116
Felis catus ARL5B VGNC VGNC:59925
Bos taurus ARL5B VGNC VGNC:26148
Macaca mulatta ARL5B VGNC VGNC:69886
Mus musculus ARL5B MGD MGI:1923119
Rattus norvegicus ARL5B RGD RGD:1305569
Others ARL5B NCBI