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Rap1A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Farnesyl Transferase (3) GGTase (2) P2X Receptor (1) Protein Prenyltransferase (2) Ras (3) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (10) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15871

GGTI298 Trifluoroacetate Maximum Cited Publications 7 Publications Verification	Apoptosis	Cancer
GGTI298 Trifluoroacetate is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit *Rap1A* with IC₅₀ of 3 μM; little effect on Ha-Ras with IC₅₀ of >20 μM.

HY-123242

FTI-2153	Farnesyl Transferase	Cancer
FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity ^[1].

HY-100876

GGTI298	Apoptosis	Cancer
GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC₅₀ values of 3 and > 20 μM in vivo, respectively.

HY-12369

GGTI-2133 1 Publications Verification	GGTase	Inflammation/Immunology
GGTI-2133, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 can be used for the study of eosinophilic airway inflammation such as asthma ^[1] .

HY-115489

GGTI-286	Ras	Cancer
GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s=2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM ^[1] .

HY-115489A

GGTI-286 TFA	Protein Prenyltransferase	Cancer
GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM ^[1] .

HY-16322

Minodronic acid 1 Publications Verification YM-529	P2X Receptor Apoptosis Farnesyl Transferase	Metabolic Disease Cancer
Minodronic acid (YM-529) is an FPP synthase inhibitor with an IC₅₀ of 3 nM, and also an antagonist of P2X2/3 receptors with an IC₅₀ of 62.7 μM. Minodronic acid induces tumor cell apoptosis and inhibits cell growth. Minodronic acid also suppresses bone resorption. Minodronic acid can be used in research related to osteoporosis and cancer ^[1] .

HY-RS16300

Rap1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Cancer
Rap1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rap1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rap1a Mouse Pre-designed siRNA Set A Rap1a Mouse Pre-designed siRNA Set A

HY-RS11652

RAP1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAP1A Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1A Human Pre-designed siRNA Set A RAP1A Human Pre-designed siRNA Set A

HY-12369A

GGTI-2133 TFA	GGTase	Inflammation/Immunology
GGTI-2133 TFA, a peptidomimetic, is a selective geranylgeranyltransferase I (GGTase-I) inhibitor with an IC₅₀ of 38 nM. GGTI-2133 TFA shows 140-fold selectivity over farnesyltransferase (FTase) (IC₅₀ of 5.4 μM). GGTI-2133 TFA inhibits the geranylation of Rap-1A with an IC₅₀ of 10 μM. GGTI-2133 TFA can be used for the study of eosinophilic airway inflammation such as asthma ^[1] .

HY-120271

GGTI-297	Ras	Cancer
GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC₅₀ values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras ^[1] .

HY-123242A

FTI-2153 TFA	Farnesyl Transferase	Cancer
FTI-2153 TFA is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC₅₀ of 1.4 nM. FTI-2153 TFA is >3000-fold more potent at blocking H-Ras (IC₅₀, 10 nM) than Rap1A processing. Anti-cancer activity ^[1].

HY-120229

GGTI-2147	Protein Prenyltransferase	Neurological Disease
GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia ^[1].

HY-117935

GGTI-286 hydrochloride	Ras	Cancer
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC₅₀=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC₅₀s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC₅₀ of 1 μM ^[1] .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (2) Mouse (3)
Application:	IP (2) WB (3) FC (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87048

	RAP1A + RAP1B Antibody (YA6741) C21KG antibody; G 22K antibody; G-22K antibody; GTP binding protein smg p21A antibody; GTP-binding protein smg p21A antibody; KREV 1 antibody; KREV1 antibody; OTTHUMP00000013741 antibody; Rap 1A antibody; Rap1 antibody; C21KG antibody; G 22K antibody; G-22K antibody; GTP binding protein smg p21A antibody; GTP-binding protein smg p21A antibody; KREV 1 antibody; KREV1 antibody; OTTHUMP00000013741 antibody; Rap 1A antibody; Rap1 antibody; Rap1A antibody; Rap1A member of RAS oncogene family antibody; Rap1A_HUMAN antibody; Ras related protein Krev 1 antibody; Ras related protein Rap 1A antibody; RAS related protein Rap1A antibody; Ras-related protein Krev-1 antibody; Ras-related protein Rap-1A antibody; SMGP21 antibody; GTP-binding protein smg p21B antibody; K-REV antibody; OK/SW-cl.11 antibody; RAL1B antibody; Rap1b antibody; Rap1B member of RAS oncogene family antibody; Rap1B_HUMAN antibody; Ras family small GTP binding protein Rap1B antibody; RAS related protein Rap1B antibody; Ras-related protein Rap-1b antibody; Small GTP binding protein antibody;	WB, FC	Human, Mouse
	RAP1A + RAP1B Antibody (YA6741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAP1A + RAP1B.

HY-P82079

	RAP1A+RAP1B Antibody (YA1824) Ras-related protein Rap-1b; K-REV; RAL1B	WB, IP, FC	Human, Mouse, Rat
	RAP1A+RAP1B Antibody (YA1824) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAP1A+RAP1B.

HY-P82079A

	RAP1A+RAP1B Antibody (YA1824)(PBS only) Ras-related protein Rap-1b; K-REV; RAL1B	WB, IP, FC	Human, Mouse, Rat
	RAP1A+RAP1B Antibody (YA1824) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAP1A+RAP1B.

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Rap1a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rap1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rap1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAP1A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RAP1A Human Pre-designed siRNA Set A contains three designed siRNAs for RAP1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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