191102-87-1
Chemical Structure
GGTI-2147
- CAS No.: 191102-87-1
- Formula:C28H30N4O3
- Molecular Weight:470.56
IUPAC Name: methyl (4-(((1H-imidazol-5-yl)methyl)amino)-2-(naphthalen-1-yl)benzoyl)-L-leucinate
InChIKey: TUQRZGWNDBXSNP-SANMLTNESA-N
SMILES: CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NCC2=CN=CN2)C=C1C3=C4C=CC=CC4=CC=C3)=O
Biological Activity: GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia[1].
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GGTI-2147 | GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia. | |||||||||||||||||||||
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Keywords
