1102 Results for "

SARS+CoV2

" in MedChemExpress (MCE) Product Catalog:
Products (1102)

1102 Results for "SARS+CoV2" in MCE Product Catalog:

1197
Chloroquine phosphate
Chloroquine phosphate
0 Images
1197 Publications Verification
Cat. No.: HY-17589
CAS No.: 50-63-5
Target:  

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:  

Infection Inflammation/Immunology Cancer

Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) [2] .
1197
Chloroquine
Chloroquine
0 Images
1197 Publications Verification
Cat. No.: HY-17589A
CAS No.: 54-05-7
Target:  

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:  

Infection Inflammation/Immunology Cancer

Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) [2] .
1197
Chloroquine dihydrochloride
Chloroquine dihydrochloride
0 Images
1197 Publications Verification
Cat. No.: HY-17589B
CAS No.: 3545-67-3
Target:  

Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:  

Infection Inflammation/Immunology Cancer

Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) [2] .
193
Chloroquine phosphate (Standard)
Chloroquine phosphate (Standard)
0 Images
193 Cited Publications
Cat. No.: HY-17589R
CAS No.: 50-63-5
Target:  

Reference Standards Parasite Autophagy SARS-CoV Toll-like Receptor (TLR) HIV Antibiotic

Research Areas:  

Infection Inflammation/Immunology Cancer

Chloroquine (phosphate) (Standard) is the analytical standard of Chloroquine (phosphate). This product is intended for research and analytical applications. Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM) [2] .
142
Thapsigargin
Thapsigargin
0 Images
142 Cited Publications
Cat. No.: HY-13433
CAS No.: 67526-95-8
Purity:  99.87%
Category:  

Infection Terpenoids Diterpenoids Plants Umbelliferae Disease Research Fields Cancer Thapsia garganica L.

Target:  

Calcium Channel SARS-CoV Apoptosis

Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca 2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types [2] .
110
Nirmatrelvir
Nirmatrelvir
0 Images
110 Cited Publications
Cat. No.: HY-138687
CAS No.: 2628280-40-8
Purity:  99.74%
Synonyms: PF-07321332
Target:  

SARS-CoV

Research Areas:  

Infection Inflammation/Immunology

Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CL PRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .
88
Hydroxychloroquine sulfate
Hydroxychloroquine sulfate
0 Images
88 Cited Publications
Cat. No.: HY-B1370
CAS No.: 747-36-4
Synonyms: HCQ sulfate
Target:  

Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy

Research Areas:  

Infection Cancer

Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro [2] .
88
Hydroxychloroquine
Hydroxychloroquine
0 Images
88 Cited Publications
Cat. No.: HY-W031727
CAS No.: 118-42-3
Target:  

Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy

Research Areas:  

Infection Cancer

Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling [2] .
74
Molnupiravir
Molnupiravir
0 Images
74 Cited Publications
Cat. No.: HY-135853
CAS No.: 2492423-29-5
Purity:  99.85%
Synonyms: EIDD-2801; MK-4482
Target:  

SARS-CoV Influenza Virus

Research Areas:  

Infection

Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza [2].
61
Leupeptin hemisulfate
Leupeptin hemisulfate
0 Images
61 Cited Publications
Cat. No.: HY-18234A
CAS No.: 103476-89-7
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Cathepsin Ser/Thr Protease Virus Protease

Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M pro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity [2] .
48
Ivermectin
Ivermectin
0 Images
48 Cited Publications
Cat. No.: HY-15310
CAS No.: 70288-86-7
Purity:  98.28%
Synonyms: MK-933; CD-5024; K-237
Category:  

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:  

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import [2] . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
45
Simeprevir
Simeprevir
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45 Cited Publications
Cat. No.: HY-10241
CAS No.: 923604-59-5
Purity:  98.79%
Synonyms: TMC435; TMC435350
Target:  

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:  

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .
44
Hydroxychloroquine sulfate (Standard)
Hydroxychloroquine sulfate (Standard)
0 Images
44 Cited Publications
Cat. No.: HY-B1370R
CAS No.: 747-36-4
Synonyms: HCQ sulfate (Standard)
Target:  

Reference Standards Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy

Research Areas:  

Infection Cancer

Hydroxychloroquine (sulfate) (Standard) is the analytical standard of Hydroxychloroquine (sulfate). This product is intended for research and analytical applications. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro [2] .
44
Telaprevir
Telaprevir
0 Images
44 Cited Publications
Cat. No.: HY-10235
CAS No.: 402957-28-2
Purity:  99.54%
Synonyms: VX-950
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide [2] . Telaprevir inhibits SARS-CoV-2 3CL pro activity .
43
Camostat mesylate
Camostat mesylate
0 Images
43 Cited Publications
Cat. No.: HY-13512
CAS No.: 59721-29-8
Purity:  99.94%
Synonyms: Camostat mesilate; FOY305; FOY-S980
Category:  

Human Gut Microbiota Metabolites Endogenous metabolite

Target:  

Ser/Thr Protease SARS-CoV

Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase [2] .
42
Asunaprevir
Asunaprevir
0 Images
42 Cited Publications
Cat. No.: HY-14434
CAS No.: 630420-16-5
Purity:  99.84%
Synonyms: BMS-650032
Target:  

HCV HCV Protease SARS-CoV

Research Areas:  

Infection

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM . Asunaprevir inhibits SARS-CoV-2 3CL pro activity .
42
Bardoxolone methyl
Bardoxolone methyl
0 Images
42 Cited Publications
Cat. No.: HY-13324
CAS No.: 218600-53-4
Purity:  98.92%
Synonyms: RTA 402; NSC 713200; CDDO Methyl ester
Target:  

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:  

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) [2] .
34
Boceprevir
Boceprevir
0 Images
34 Cited Publications
Cat. No.: HY-10237
CAS No.: 394730-60-0
Purity:  98.52%
Synonyms: EBP 520; SCH 503034
Target:  

HCV Protease HCV SARS-CoV

Research Areas:  

Infection

Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay [2] . Boceprevir inhibits SARS-CoV-2 3CL pro activity .
34
Paquinimod
Paquinimod
0 Images
34 Cited Publications
Cat. No.: HY-100442
CAS No.: 248282-01-1
Purity:  99.90%
Synonyms: ABR-215757; ABR 25757
Target:  

SARS-CoV

Research Areas:  

Metabolic Disease Inflammation/Immunology

Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice [2] .
33
GSK3326595
GSK3326595
0 Images
33 Cited Publications
Cat. No.: HY-101563
CAS No.: 1616392-22-3
Purity:  99.51%
Synonyms: EPZ015938
Target:  

Histone Methyltransferase SARS-CoV MDM-2/p53 CDK Apoptosis

Research Areas:  

Infection Cancer

GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma [2] .
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