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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
STK11
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "STK11" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N6904
CAS No.: 25368-09-6
Category:
Neurological Disease Terpenoids Lridaceae Diterpenoids Plants Crocus sativus L. Disease Research Fields Inflammation/Immunology
Target:
TNG260 is a selective, orally effective inhibitor of HDAC1 and CoREST complex, with a 10-fold selectivity for HDAC1 over HDAC3 and a 500-fold selectivity for CoREST complex over NuRD and Sin3 complex. TNG260 reshapes the tumor immune microenvironment, reduces immunosuppressive neutrophil infiltration, promotes effector T cell recruitment, and reverses anti-PD-1 resistance caused by STK11 deficiency by inhibiting the activity of the CoREST-HDAC1 complex. TNG260 induces durable tumor regression in combination with α-PD1 in MC38 tumor-bearing mice with STK11 mutations, and has lower toxicity to bone marrow cells than non-selective HDAC inhibitors .
Cat. No.: HY-RS13921
Target:
Research Areas:
STK11 Human Pre-designed siRNA Set A contains three designed siRNAs for STK11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P5435
CAS No.: 835653-81-1
Target:
Research Areas:
(S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
Cat. No.: HY-RS17308
Target:
Research Areas:
Stk11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stk11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23763
Target:
Research Areas:
Stk11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stk11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N6904R
CAS No.: 25368-09-6
Category:
Target:
Cat. No.: HY-RS13922
Target:
Research Areas:
STK11IP Human Pre-designed siRNA Set A contains three designed siRNAs for STK11IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P71549
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: hLKB1; Liver kinase B1; LKB1; PJS; Polarization related protein LKB1; Renal carcinoma antigen NY-REN-19; Serine/Threonine Kinase 11; Serine/threonine protein kinase 11; Serine/threonine protein kinase LKB1; Serine/threonine protein kinase STK11; Serine/threonine-protein kinase 11; Serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase XEEK1; STK11; STK11_HUMAN
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
