2935964-93-3
2935964-93-3
Chemical Structure
(S)-TNG260
- CAS No.: 2935964-93-3
- Formula:C20H18FN3O2S
- Molecular Weight:383.44
InChIKey: JPFMYSJUFUEHBI-MHZLTWQESA-N
SMILES: NC1=CC=C(C2=CC=C(F)C=C2)C=C1NC(C3=CC=C([S@@](=O)(C)=N)C=C3)=O
Biological Activity: (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(S)-TNG260 | 98.39% | (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
