2935964-93-3

(S)-TNG260 Chemical Structure
2935964-93-3

Chemical Structure

(S)-TNG260

  • CAS No.: 2935964-93-3
  • Formula:C20H18FN3O2S
  • Molecular Weight:383.44

InChIKey: JPFMYSJUFUEHBI-MHZLTWQESA-N

SMILES: NC1=CC=C(C2=CC=C(F)C=C2)C=C1NC(C3=CC=C([S@@](=O)(C)=N)C=C3)=O

Biological Activity: (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.

Cat. No. Product Name Purity Description Pricing
HY-153358A 		(S)-TNG260 98.39% (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
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