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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
TGFbR1
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "TGFbR1" in MCE Product Catalog:
4
4 Cited Publications
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Research Areas:
PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction.?PF-06952229 is a promising antineoplastic?agent for the study solid tumors, especifically metastatic breast cancer [1].
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4 Cited Publications
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Research Areas:
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth [1].
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1
1 Cited Publications
Cat. No.: HY-N7694
CAS No.: 97871-44-8
Category:
Triterpenes Terpenoids Melia toosendan Sieb. et Zucc. Plants Disease Research Fields Inflammation/Immunology Meliaceae
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1
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AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM. AZ12799734 is also a pan BMP and TGFβ inhibitor [1].
Cat. No.: HY-164793
CAS No.: 733806-89-8
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TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis [1].
Cat. No.: HY-174531
Human TGFBR1 mRNA encodes the human transforming growth factor beta receptor 1 (TGFBR1) protein, a serine/threonine protein kinase. TGFBR1 can form a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm.
Cat. No.: HY-RS14444
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TGFBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for TGFBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14445
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Tgfbr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tgfbr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14446
Research Areas:
TGFBR1 Rat Pre-designed siRNA Set A contains three designed siRNAs for TGFBR1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P704918
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5
Cat. No.: HY-P74522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
