2748337-86-0

AZ12601011 Chemical Structure
2748337-86-0

Chemical Structure

AZ12601011

  • CAS No.: 2748337-86-0
  • Formula:C19H15N5
  • Molecular Weight:313.36

IUPAC Name: 2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

InChIKey: KQCNNLRNSIXEJU-UHFFFAOYSA-N

SMILES: C1(C2=NC=CC=C2)=NC(N3C=CC4=C3C=CN=C4)=C(CCC5)C5=N1

Biological Activity: AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth [1].

Cat. No. Product Name Purity Description Pricing
HY-122856 		AZ12601011 99.78% AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth .
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