11 Results for "

Tbet

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "Tbet" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-119347
CAS No.: 41365-32-6
Purity:  ≥98.0%
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 + T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N4087
CAS No.: 66663-90-9
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .
loading...
    loading...
Cat. No.: HY-N0600
CAS No.: 62025-50-7
Ginsenoside F3 is a saponin extracted from the leaves of Panax ginseng with immunoenhancing and antitumor immunostimulatory activities. Ginsenoside F3 upregulates RIPOR2 with a Kd value of 3.77 μM. Ginsenoside F3 enhances NF‑κB activation, upregulates T‑bet and downregulates GATA‑3, increases the production of IL‑2 and IFN‑γ, decreases the production of IL‑4 and IL‑10, reverses CD8⁺ T‑cell exhaustion, restores cytokine secretion, and enhances antitumor immunity in a mouse non‑small cell lung cancer model. Ginsenoside F3 can be used for the research of non-small cell lung cancer .
loading...
    loading...
Cat. No.: HY-P991180

Target:  

TNF Receptor

Research Areas:  

Cancer

TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].
loading...
    loading...
Cat. No.: HY-RS14277
Research Areas:  

Others

TBX21 Human Pre-designed siRNA Set A contains three designed siRNAs for TBX21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-119347R
CAS No.: 41365-32-6
Cirsilineol (Standard) is the analytical standard of Cirsilineol. This product is intended for research and analytical applications. Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice .
loading...
    loading...
Cat. No.: HY-P81757
Synonyms: T bet; T box 21; T PET; Tbet; TBLYM; Tbx21; TPET; Transcription factor TBLYM

Host:  

Rabbit

Application:  

IHC-P, FC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P81472A
Synonyms: T bet; T box 21; T PET; Tbet; TBLYM; Tbx21; TPET; Transcription factor TBLYM; T Box Protein 21

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P81472
Synonyms: T bet; T box 21; T PET; Tbet; TBLYM; Tbx21; TPET; Transcription factor TBLYM; T Box Protein 21

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-RS21062
Research Areas:  

Others

Tbx21 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tbx21 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-P85868
Synonyms: T-box transcription factor TBX21; T-box protein 21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM;

Host:  

Mouse

Application:  

WB, ICC/IF, ELISA

Reactivity:  

Human, Mouse

loading...
    loading...
  • 1