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Thiouracil

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) DNA/RNA Synthesis (2) Environmental Pollutants (1) Fungal (1) Glutathione Peroxidase (2) Isotope-Labeled Compounds (6) NO Synthase (2) Nucleoside Antimetabolite/Analog (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Thyroid Hormone Receptor (2) TSH Receptor (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (5) Infection (1)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0346

Propylthiouracil 3 Publications Verification 6-n-PropylThiouracil; 6-Propyl-2-Thiouracil; PTU	Environmental Pollutants Thyroid Hormone Receptor	Endocrinology
Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .

HY-100873

PF-1355 3 Publications Verification PF-06281355	Glutathione Peroxidase	Cardiovascular Disease
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.

HY-B0503

2-Thiouracil 2 Publications Verification Thiouracil	NO Synthase	Endocrinology Cancer
2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a K_i value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments .

HY-W010417

4-Thiouracil	Reactive Oxygen Species (ROS)	Others
4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O2. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy .

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Fungal	Infection
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

HY-W069177

Benzylthiouracil 6-Benzyl-2-Thiouracil	TSH Receptor	Others
Benzylthiouracil is an active pharmaceutical ingredient against hyperthyroidism .

HY-B0346R

Propylthiouracil (Standard) 6-n-PropylThiouracil (Standard); 6-Propyl-2-Thiouracil (Standard); PTU (Standard)	Thyroid Hormone Receptor Reference Standards	Endocrinology
Propylthiouracil (Standard) is the analytical standard of Propylthiouracil. This product is intended for research and analytical applications. Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research .

HY-B0503S

*2-Thiouracil-13C,15N2* Thiouracil-¹³C,¹⁵N₂	Isotope-Labeled Compounds NO Synthase	Endocrinology Cancer
2-Thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

HY-W052750

5-Carboxy-2-thiouracil	Biochemical Assay Reagents
5-Carboxy-2-thiouracil is a compound with antitumor activity that can form complexes with metal ions, thereby exhibiting significant biological effects.

HY-W778297

*5,6-Diamino-4-thiouracil-13C2*	Isotope-Labeled Compounds	Others
5,6-Diamino-4-thiouracil- ¹³C₂ is the ¹³C-labeled 5,6-Diamino-4-thiouracil (HY-W740396).

HY-W012478S

*6-Phenyl-2-thiouracil-13C,15N2*	Isotope-Labeled Compounds	Others
6-Phenyl-2-thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 6-Phenyl-2-thiouracil.

HY-152343

1-(β-D-Xylofuranosyl)-2-thiouracil	Nucleoside Antimetabolite/Analog	Others
1-(β-D-Xylofuranosyl)-2-thiouracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-B0346S

Propylthiouracil-d5 6-n-PropylThiouracil-d₅; 6-Propyl-2-Thiouracil-d₅; PTU-d₅	Isotope-Labeled Compounds	Endocrinology
Propylthiouracil-d₅ is the deuterium labeled Propylthiouracil. Propylthiouracil (6-Propyl-2-thiouracil) is a thyroperoxidase and 5'-deiodinase inhibitor.

HY-W766699

6-Amino-4-hydroxy-2-mercaptopyrimidine-13C 6-Amino-2-Thiouracil Monohydrate-¹³C	Isotope-Labeled Compounds	Others
6-Amino-4-hydroxy-2-mercaptopyrimidine- ¹³C (6-Amino-2-thiouracil Monohydrate- ¹³C) is the ¹³C-labeled 6-Amino-4-hydroxy-2-mercaptopyrimidine (HY-75601).

HY-W777759

*6-Amino-5-nitroso-2-thiouracil-13C,15N* 4-Amino-6-hydroxy-2-mercapto-5-nitrosopyrimidine-¹³C,¹⁵N	Isotope-Labeled Compounds	Others
6-Amino-5-nitroso-2-thiouracil- ¹³C, ¹⁵N (4-Amino-6-hydroxy-2-mercapto-5-nitrosopyrimidine- ¹³C, ¹⁵N) is the ¹³C- and ¹⁵N-labeled 6-Amino-5-nitroso-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (HY-75602).

HY-100873R

PF-1355 (Standard) PF-06281355 (Standard)	Glutathione Peroxidase Reference Standards	Cardiovascular Disease
PF-1355 (Standard) is the analytical standard of PF-1355 (HY-100873). This product is intended for research and analytical applications. PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.

HY-P11685

*Fmoc-PNA-thioU(PMB)-OH*	DNA/RNA Synthesis	Others
Fmoc-PNA-thioU(PMB)-OH is a nucleobase-modified peptide nucleic acid (PNA) monomer used in solid-phase synthesis. Fmoc-PNA-thioU(PMB)-OH features a thiouracil base protected with a p-methoxybenzyl (PMB) group on an Fmoc-protected backbone, designed for incorporating modified PNA bases into oligonucleotides to study binding properties.

HY-P11680

*Boc-PNA-thioU(PMB)-OH*	DNA/RNA Synthesis	Others
BOC-PNA-thioU(PMB)-OH is a peptide nucleic acid (PNA) monomer characterized by a PMB protecting group on its thiouracil, which enhances its binding affinity to adenine. BOC-PNA-thioU(PMB)-OH exhibits excellent resistance to enzymatic degradation and strong hybridization properties, making it valuable for applications in gene diagnosis, antisense therapy, and other molecular biology fields requiring higher binding strength and greater functionalization.

5-Carboxy-2-thiouracil	Biochemical Assay Reagents
5-Carboxy-2-thiouracil is a compound with antitumor activity that can form complexes with metal ions, thereby exhibiting significant biological effects.

Cat. No.	Product Name	Target	Research Area

HY-P11685

*Fmoc-PNA-thioU(PMB)-OH*	DNA/RNA Synthesis	Others
Fmoc-PNA-thioU(PMB)-OH is a nucleobase-modified peptide nucleic acid (PNA) monomer used in solid-phase synthesis. Fmoc-PNA-thioU(PMB)-OH features a thiouracil base protected with a p-methoxybenzyl (PMB) group on an Fmoc-protected backbone, designed for incorporating modified PNA bases into oligonucleotides to study binding properties.

HY-P11680

*Boc-PNA-thioU(PMB)-OH*	DNA/RNA Synthesis	Others
BOC-PNA-thioU(PMB)-OH is a peptide nucleic acid (PNA) monomer characterized by a PMB protecting group on its thiouracil, which enhances its binding affinity to adenine. BOC-PNA-thioU(PMB)-OH exhibits excellent resistance to enzymatic degradation and strong hybridization properties, making it valuable for applications in gene diagnosis, antisense therapy, and other molecular biology fields requiring higher binding strength and greater functionalization.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-128425A

N-Carbamoyl-L-aspartic acid 1 Publications Verification L-Ureidosuccinic acid	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Fungal
N-Carbamoyl-L-aspartic acid (L-Ureidosuccinic acid) is an important pyrimidine metabolic precursor and intermediate metabolite. N-Carbamoyl-L-aspartic acid reverses the growth inhibition of Ura ⁺ strains induced by 2-thiouracil (with growth rate increasing linearly with its concentration), but fails to support the growth of uracil-requiring Ura ^- strains. N-Carbamoyl-L-aspartic acid inhibits the cell growth of Saccharomyces cerevisiae by suppressing the purine biosynthetic pathway at a pre-step of 5-aminoimidazole nucleotide synthesis. The growth inhibitory effect of N-Carbamoyl-L-aspartic acid on yeast can be alleviated by purines, and the sensitivity of strains is closely related to the activity level of dihydroorotase .

Cat. No.	Product Name	Chemical Structure

HY-B0503S

*2-Thiouracil-13C,15N2*
2-Thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

HY-W778297

*5,6-Diamino-4-thiouracil-13C2*
5,6-Diamino-4-thiouracil- ¹³C₂ is the ¹³C-labeled 5,6-Diamino-4-thiouracil (HY-W740396).

HY-W012478S

*6-Phenyl-2-thiouracil-13C,15N2*
6-Phenyl-2-thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 6-Phenyl-2-thiouracil.

HY-B0346S

Propylthiouracil-d5
Propylthiouracil-d₅ is the deuterium labeled Propylthiouracil. Propylthiouracil (6-Propyl-2-thiouracil) is a thyroperoxidase and 5'-deiodinase inhibitor.

HY-W766699

6-Amino-4-hydroxy-2-mercaptopyrimidine-13C
6-Amino-4-hydroxy-2-mercaptopyrimidine- ¹³C (6-Amino-2-thiouracil Monohydrate- ¹³C) is the ¹³C-labeled 6-Amino-4-hydroxy-2-mercaptopyrimidine (HY-75601).

HY-W777759

*6-Amino-5-nitroso-2-thiouracil-13C,15N*
6-Amino-5-nitroso-2-thiouracil- ¹³C, ¹⁵N (4-Amino-6-hydroxy-2-mercapto-5-nitrosopyrimidine- ¹³C, ¹⁵N) is the ¹³C- and ¹⁵N-labeled 6-Amino-5-nitroso-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (HY-75602).

Cat. No.	Product Name		Classification

HY-152343

1-(β-D-Xylofuranosyl)-2-thiouracil		Nucleoside Analogs Uridine
1-(β-D-Xylofuranosyl)-2-thiouracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

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Thiouracil

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products