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TweakR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (1) Small Interfering RNA (siRNA) (2) STAT (1) TNF Receptor (3)
By Research Areas:	Cancer (2) Inflammation/Immunology (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TweakR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P991439

BIIB023	TNF Receptor	Inflammation/Immunology
BIIB023 is a human monoclonal antibody (mAb) targeting *TNFRSF12A/TWEAKR/CD266*. BIIB023 can be used in lupus nephritis and rheumatoid arthritis research .

HY-RS14803

TNFRSF12A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF12A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNFRSF12A Human Pre-designed siRNA Set A TNFRSF12A Human Pre-designed siRNA Set A

HY-RS17480

Tnfrsf12a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf12a Mouse Pre-designed siRNA Set A Tnfrsf12a Mouse Pre-designed siRNA Set A

HY-P992321

BAY-356	TNF Receptor NF-κB STAT	Cancer
BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer^[1]^[2].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TweakR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P991439

BIIB023	TNF Receptor	Inflammation/Immunology
BIIB023 is a human monoclonal antibody (mAb) targeting *TNFRSF12A/TWEAKR/CD266*. BIIB023 can be used in lupus nephritis and rheumatoid arthritis research .

HY-P992321

BAY-356	TNF Receptor NF-κB STAT	Cancer
BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer^[1]^[2].

Species:	Human (2) Mouse (1)
Tag:	Tag Free (1) Fc (2)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71909

	TNFRSF12A Protein, Human CD 266; CD266; CD266 antigen; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNFRSF12A; TNR12_HUMAN; Tumor necrosis factor receptor superfamily member 12A; TWEAK R; Tweak receptor; Tweak-receptor; TweakR	Human	E. coli
	TNFRSF12A Protein, the receptor for TNFSF12/TWEAK, acts as a weak apoptosis inducer in specific cell types. It also promotes angiogenesis, endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. Association with TRAF1, TRAF2, and potentially TRAF3 underscores its involvement in diverse cellular signaling pathways. TNFRSF12A Protein, Human is the recombinant human-derived TNFRSF12A protein, expressed by E. coli , with tag free.

HY-P72435

	TNFRSF12A Protein, Mouse (HEK293, Fc) TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and tweak-receptor	Mouse	HEK293
	TNFRSF12A Protein, a receptor for TNFSF12/TWEAK, exhibits a weak apoptosis-inducing ability in specific cells.It promotes angiogenesis and endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins.In functional interactions, TNFRSF12A associates with TRAF1 and TRAF2, possibly with TRAF3, suggesting its involvement in signaling pathways contributing to diverse cellular processes.TNFRSF12A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72434

	TNFRSF12A Protein, Human (HEK293, Fc) 1 Publications Verification TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and tweak-receptor	Human	HEK293
	TNFRSF12A Protein, the receptor for TNFSF12/TWEAK, acts as a weak apoptosis inducer in specific cell types. It also promotes angiogenesis, endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. Association with TRAF1, TRAF2, and potentially TRAF3 underscores its involvement in diverse cellular signaling pathways. TNFRSF12A Protein, Human (HEK293, Fc) is the recombinant human-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) IF-Tissue (1) IP (3) WB (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P82931

	CD266 Antibody (YA2676) CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; FN14; TNFRSF 12A; Tweak receptor; TweakR	WB, IHC-P, IP	Human, Mouse, Rat
	CD266 Antibody (YA2676) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD266.

HY-P810450

	TNFSF12 Antibody (YA9755) FN14, TNFRSF 12A, Tweak receptor, TweakR,	WB, IHC-P, ICC/IF, IF-Tissue, IP	Human, Mouse, Rat
	TNFSF12 Antibody (YA9755) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to TNFSF12.

HY-P82931A

	CD266 Antibody (YA2676)(PBS only) CD266 antigen; FGF inducible 14; Fibroblast growth factor inducible immediate early response protein 14; FN14; TNFRSF 12A; Tweak receptor; TweakR	WB, IHC-P, IP	Human, Mouse, Rat
	CD266 Antibody (YA2676) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD266.

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TNFRSF12A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNFRSF12A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf12a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tnfrsf12a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf12a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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