2. Apoptosis NF-κB Stem Cell/Wnt JAK/STAT Signaling
  3. TNF Receptor NF-κB STAT
  4. BAY-356

BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer[1][2].

For research use only. We do not sell to patients.

BAY-356

BAY-356 Chemical Structure

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BAY-356 Related Antibodies

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Description

BAY-356, a potent TWEAK receptor agonist, is an aglycosylated anti-TWEAK receptor antibody. BAY-356 triggers TWEAKR hyperactivation, activates NFκB and STAT1 pathways, and undergoes TWEAKR-dependent internalization. BAY-356 can be used for the research of colorectal cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer[1][2].

Species Reactivity

Human
IC50 & Target[1]

TWEAK

 

NF-κB

 

STAT1

 

In Vitro

BAY-356 induces dose-dependent agonistic effects in TWEAK receptor-positive tumor cells, activating NFκB and STAT1 pathways, increasing TWEAKR expression and IL-8 secretion, activating caspase 3/7, and inhibiting proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-356 Related Antibodies
In Vivo

BAY-356 (3-10 mg/kg; twice weekly; up to 3 weeks) inhibits tumor growth by 49-71% in TWEAK receptor-positive solid tumor xenograft models[1].
BAY-356 (1-40 mg/kg; i.v.; weekly; 4 weeks) at 10 mg/kg results in well-tolerated exposure in healthy Cynomolgus monkeys, with higher doses (20 and 40 mg/kg) causing slight to moderate organ toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys (healthy)[2]
Dosage: 10 mg/kg; 20 mg/kg; 40 mg/kg
Administration: i.v.; once a week; 4 weeks
Result: Associated well-tolerated exposure with 10 mg/kg weekly dose (not exceeding toxic thresholds).
Caused slight to moderate toxicity in liver, kidneys, and pancreas with 10, 20, and 40 mg/kg weekly doses.
Gene ID

51330  [NCBI]

Accession
Target

TNFRSF12A/TWEAKR/CD266
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY-356 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-356BAY356BAY 356TNF ReceptorNF-κBSTATTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBBxPC3STAT1TWEAK receptorCynomolgus monkeysFN14LoVoIL-8caspase 3/7NFκBNCI-H292Inhibitorinhibitorinhibit

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