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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
UHRF1
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "UHRF1" in MCE Product Catalog:
9
5
5 Cited Publications
Target:
Research Areas:
NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.
3
3 Cited Publications
SKF-83566 is an orally active, blood-brain barrier-permeable D1/D5 dopamine receptor antagonist with a Ki value of approximately 0.4-0.56 nM.
SKF-83566 modulates locomotor behavior and spatial memory by blocking D1 receptors and inhibits glioblastoma progression by targeting the DRD1/c-Myc/UHRF1 pathway.
SKF-83566 acts as an inhibitor of the dopamine transporter (DAT) and adenylyl cyclase 2 (AC2).
SKF-83566 competitively binds to DAT to inhibit dopamine reuptake and non-competitively inhibits AC2 activity, thereby reducing cAMP accumulation.
SKF-83566 is used in research areas such as dopaminergic system mechanisms, learning and memory, targeted intervention for glioblastoma, AC2 pathophysiology, antiparasitic drug screening, and synaptic plasticity (the "gating effect") [1] .
Research Areas:
NV03 is a potent and selective antagonist of Ubiquitin-like with PHD and RING finger domains 1 (UHRF1)-H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 is also a ligand for E3 ligase. NV03 can be studied in anticancer research [1] .
Cat. No.: HY-RS15445
Target:
Research Areas:
UHRF1 Human Pre-designed siRNA Set A contains three designed siRNAs for UHRF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W004883
CAS No.: 1193-71-1
Synonyms: 5A-DMP
Target:
Research Areas:
3-Amino-4,6-dimethylpyridine (5A-DMP) is a UHRF1 inhibitor that targets the Arg-binding cavity site within the UHRF1 TTD domain. 3-Amino-4,6-dimethylpyridine disrupts the interaction between UHRF1 and LIG1, interfering with DNA methylation, and can be utilized in cancer research [1].
Cat. No.: HY-173002
CAS No.: 3107482-42-5
Target:
Research Areas:
MS9024 is a selective DNMT1 Molecular glue degrader with a DC50 of 35 nM. MS9024 degrades DNMT1 in a concentration-, time- and proteasome-dependent manner without altering DNMT1 transcription. MS9024 mediates degradation via HECT E3 ligase and/or UHRF1, but not via lysosomes or Cullin RING E3 ligase. MS9024 can be used in the research of colorectal cancer, breast cancer and non-small cell lung cancer [1].
Cat. No.: HY-RS16683
Target:
Research Areas:
Uhrf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uhrf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23118
Target:
Research Areas:
Uhrf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uhrf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182956
CAS No.: 2962943-72-0
Target:
Research Areas:
DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC50 of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with DNMT1 and UHRF1, thereby triggering UHRF1-mediated ubiquitination and degradation of DNMT1, and inhibiting the enzymatic activity of DNMT1. DNMT1 Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia [1].
Cat. No.: HY-P85479
Synonyms: UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquit
Cat. No.: HY-P81313A
Synonyms: Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95
Cat. No.: HY-P81313AA
Synonyms: Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95
Cat. No.: HY-P703623
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: UHRF1; Ubiquitin Like With PHD And Ring Finger Domains 1; ICBP90; RNF106; TDRD22; Np95; Ubiquitin‑Like PHD And RING Finger Domain‑Containing Protein 1; Inverted CCAAT Box‑Binding Protein Of 90 KDa; Inverted CCAAT Box Binding Protein 90; E3 Ubiquitin‑Prote
Cat. No.: HY-P703624
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: UHRF1; Ubiquitin Like With PHD And Ring Finger Domains 1; ICBP90; RNF106; TDRD22; Np95; Ubiquitin‑Like PHD And RING Finger Domain‑Containing Protein 1; Inverted CCAAT Box‑Binding Protein Of 90 KDa; Inverted CCAAT Box Binding Protein 90; E3 Ubiquitin‑Prote
Cat. No.: HY-103430B
CAS No.: 164265-49-0
Research Areas:
SKF-83566 hydrochloride is an orally active, blood-brain barrier-permeable D1/D5 dopamine receptor antagonist with a Ki value of approximately 0.4-0.56 nM.
SKF-83566 hydrochloride modulates locomotor behavior and spatial memory by blocking D1 receptors and inhibits glioblastoma progression by targeting the DRD1/c-Myc/UHRF1 pathway.
SKF-83566 hydrochloride acts as an inhibitor of the dopamine transporter (DAT) and adenylyl cyclase 2 (AC2).
SKF-83566 hydrochloride competitively binds to DAT to inhibit dopamine reuptake and non-competitively inhibits AC2 activity, thereby reducing cAMP accumulation.
SKF-83566 hydrochloride is used in research areas such as dopaminergic system mechanisms, learning and memory, targeted intervention for glioblastoma, AC2 pathophysiology, antiparasitic drug screening, and synaptic plasticity (the "gating effect") [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
