2. Epigenetics PROTAC
  3. Histone Methyltransferase Ligands for E3 Ligase
  4. NV03

NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity.

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NV03 Chemical Structure

NV03 Chemical Structure

CAS No. : 2448341-58-8

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Based on 1 publication(s) in Google Scholar

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Description

NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity[1].

IC50 & Target

UHRF1, H3K9me3[1]
Molecular Weight

389.51

Formula

C19H27N5O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC(NCCCN(CC)CC)=O)N=C(C)N2C1=C(C)C3=C2C=CS3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (85.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5673 mL 12.8366 mL 25.6733 mL
5 mM 0.5135 mL 2.5673 mL 5.1347 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5673 mL 12.8366 mL 25.6733 mL 64.1832 mL
5 mM 0.5135 mL 2.5673 mL 5.1347 mL 12.8366 mL
10 mM 0.2567 mL 1.2837 mL 2.5673 mL 6.4183 mL
15 mM 0.1712 mL 0.8558 mL 1.7116 mL 4.2789 mL
20 mM 0.1284 mL 0.6418 mL 1.2837 mL 3.2092 mL
25 mM 0.1027 mL 0.5135 mL 1.0269 mL 2.5673 mL
30 mM 0.0856 mL 0.4279 mL 0.8558 mL 2.1394 mL
40 mM 0.0642 mL 0.3209 mL 0.6418 mL 1.6046 mL
50 mM 0.0513 mL 0.2567 mL 0.5135 mL 1.2837 mL
60 mM 0.0428 mL 0.2139 mL 0.4279 mL 1.0697 mL
80 mM 0.0321 mL 0.1605 mL 0.3209 mL 0.8023 mL
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NV03 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NV032448341-58-8NV 03NV-03Histone MethyltransferaseLigands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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