1. Epigenetics
    PROTAC
  2. Histone Methyltransferase
    Ligand for E3 Ligase
  3. NV03

NV03 

Cat. No.: HY-125292
Handling Instructions

NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity.

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NV03 Chemical Structure

NV03 Chemical Structure

CAS No. : 2448341-58-8

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Description

NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity[1].

IC50 & Target

UHRF1, H3K9me3[1]

Molecular Weight

389.51

Formula

C₁₉H₂₇N₅O₂S

CAS No.

2448341-58-8

SMILES

O=C1N(CC(NCCCN(CC)CC)=O)N=C(C)N2C1=C(C)C3=C2C=CS3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NV03NV 03NV-03Histone MethyltransferaseLigand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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