3107482-42-5
Chemical Structure
MS9024
- CAS No.: 3107482-42-5
- Formula:C21H22N6O2S
- Molecular Weight:422.50
InChIKey: WIJCBRHWPWIQTG-UHFFFAOYSA-N
SMILES: CCC1=C(C(SC(C2=CC=CC=C2)C(N)=O)=NC(N(CC(NC)=O)C)=C1C#N)C#N
Biological Activity: MS9024 is a selective DNMT1 Molecular glue degrader with a DC50 of 35 nM. MS9024 degrades DNMT1 in a concentration-, time- and proteasome-dependent manner without altering DNMT1 transcription. MS9024 mediates degradation via HECT E3 ligase and/or UHRF1, but not via lysosomes or Cullin RING E3 ligase. MS9024 can be used in the research of colorectal cancer, breast cancer and non-small cell lung cancer[1].
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MS9024 | 99.83% | MS9024 is a selective DNMT1 Molecular glue degrader with a DC50 of 35 nM. MS9024 degrades DNMT1 in a concentration-, time- and proteasome-dependent manner without altering DNMT1 transcription. MS9024 mediates degradation via HECT E3 ligase and/or UHRF1, but not via lysosomes or Cullin RING E3 ligase. MS9024 can be used in the research of colorectal cancer, breast cancer and non-small cell lung cancer. | ||||||||||||||||||||
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Keywords
