2962943-72-0
Chemical Structure
DNMT1 Degrader-1
- CAS No.: 2962943-72-0
- Formula:C24H32N4O2
- Molecular Weight:408.54
InChIKey: DIDDMGZNRDOWDK-UHFFFAOYSA-N
SMILES: COC1=CC2=NC(C3=CCCC3)=NC(N4CCC(N5CCCC5)CC4)=C2C=C1OC
Biological Activity: DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC50 of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with DNMT1 and UHRF1, thereby triggering UHRF1-mediated ubiquitination and degradation of DNMT1, and inhibiting the enzymatic activity of DNMT1. DNMT1 Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia[1].
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DNMT1 Degrader-1 | DNMT1 Degrader-1 is a selective DNMT1 degrader with an IC50 of 202.87 nM and a Kd value of 122 nM. As a molecular glue, DNMT1 Degrader-1 forms a ternary complex with DNMT1 and UHRF1, thereby triggering UHRF1-mediated ubiquitination and degradation of DNMT1, and inhibiting the enzymatic activity of DNMT1. DNMT1 Degrader-1 inhibits the proliferation of primary acute myeloid leukemia cells and exerts anti-tumor activity. DNMT1 Degrader-1 can be used for the research of acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
