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acarbose

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By Targets:	Amylases (2) Apoptosis (1) Cholinesterase (ChE) (1) Glutaminase (1) Glycosidase (14) Isotope-Labeled Compounds (1) Reference Standards (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (16) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0089

*Acarbose* 5+ Cited Publications BAY g 5421	Glycosidase	Infection Metabolic Disease Cancer
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-B0089R

Acarbose (Standard) BAY g 5421 (Standard)	Reference Standards Glycosidase	Metabolic Disease Cancer
Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-B0089S

Acarbose-d4 BAY g 5421-d₄	Isotope-Labeled Compounds Glycosidase	Metabolic Disease Cancer
Acarbose-d₄ (BAY g 5421-d₄) is deuterium labeled Acarbose. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-B0089A

Acarbose sulfate Bay-g 5421 sulfate	Glycosidase	Cardiovascular Disease Metabolic Disease Cancer
Acarbose (BAY g 5421) sulfate, antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC₅₀=11 nM). Acarbose sulfate can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-131504A

Valienamine	Glycosidase	Metabolic Disease
Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose .

HY-121323R

Erucin (Standard)	Reference Standards Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-161782

α-Amylase-IN-7	Amylases	Metabolic Disease
α-Amylase-IN-7 (Compound 6e) is an inhibitor for α-Amylase with an IC₅₀ of 40 μM. α-Amylase-IN-7 exhibits potential as an antidiabetic agent .

HY-168462

α-Glucosidase-IN-82	Glycosidase	Metabolic Disease
α-Glucosidase-IN-82 (compound 8l) is a potent inhibitor of α-Glucosidase, with the IC₅₀ of 13.66 μM. α-Glucosidase-IN-82 exhibits a 52-fold increase in inhibitory activity relative to Acarbose (HY-B0089) .

HY-162639

α-Glucosidase-IN-68	Glycosidase Cholinesterase (ChE)	Neurological Disease Metabolic Disease
α-Glucosidase-IN-68 (Compound 2) is an inhibitor for α-Glucosidase, AChE, and BChE, with IC₅₀ of 0.251, 0.774 and 0.793 μM, respectively. α-Glucosidase-IN-68 exhibits antioxidant efficacy, with IC₅₀ of 0.69 μM and 0.02 μM, in DPPH and ABTS experiments. α-Glucosidase-IN-68 exhibits antidiabetic effect in Streptozotocin (HY-13753)-induced diabetic rat models .

HY-147718

α-Glucosidase-IN-5	Glutaminase	Metabolic Disease
α-Glucosidase-IN-5 (compound 8) is a potent α-glucosidase inhibitor with an IC₅₀ of 57.9 µM. α-Glucosidase-IN-5 has the potential for the research of diabetes mellitus .

HY-147964

α-Glucosidase-IN-9	Glycosidase	Metabolic Disease
α-Glucosidase-IN-9 (compound 7) is a potent α-glucosidase inhibitor, with an IC₅₀ of 55.6 μM. α-Glucosidase-IN-9 can be used for type II diabetes research .

HY-147965

α-Glucosidase-IN-10	Glycosidase	Metabolic Disease
α-Glucosidase-IN-10 (compound 13) is a potent α-glucosidase inhibitor, with an IC₅₀ of 92.7 μM. α-Glucosidase-IN-10 can be used for type II diabetes research .

HY-170606

α-Glucosidase-IN-79	Glycosidase	Metabolic Disease
α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC₅₀ of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (HY-B0089) (IC₅₀ of 327.0 μM) and HXH8r (IC₅₀ of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes .

HY-176221

α-Glucosidase-IN-92	Glycosidase	Metabolic Disease
α-Glucosidase-IN-92 (compound 14b) is a non-competitive inhibitor targeting α-glucosidase (IC₅₀=64.0 μM), with better inhibitory potency than Acarbose (HY-B0089) (IC₅₀=750 μM). α-Glucosidase-IN-92 has good oral bioavailability and can cross the blood-brain barrier. α-Glucosidase-IN-92 can delay carbohydrate hydrolysis and reduce postprandial blood glucose. α-Glucosidase-IN-92 can be used in anti-glycemic research for type 2 diabetes .

HY-178170

α-Amylase/α-Glucosidase-IN-22	Amylases Glycosidase	Metabolic Disease
α-Amylase/α-Glucosidase-IN-22 is an inhibitor of α-Amylase and α-Glucosidase with IC₅₀ values of 1.71 and 10.36 nM (5 and 23.8 folds more potent than Acarbose (HY-B0089)). α-Amylase/α-Glucosidase-IN-22 can be used for the researches of metabolic disease, such as diabetes .

HY-N17717

Vitexin-2''-O-glucoside Flavosativaside	Glycosidase	Metabolic Disease
Vitexin-2''-O-glucoside (Flavosativaside) is a potent and selective alpha-glucosidase inhibitor found in hawthorn leaf flavonoids. Vitexin-2''-O-glucoside can reversibly inhibit the α-glucosidase activity on the brush border of the small intestine, and its inhibitory effect is superior to that of the Acarbose (HY-B0089). Vitexin-2''-O-glucoside can be used for the research of type 2 diabetes .

HY-181476

α-Glucosidase-IN-113	Glycosidase	Metabolic Disease
α-Glucosidase-IN-113 is an α-glucosidase inhibitor with an IC₅₀ of 17.52 μM. α-Glucosidase-IN-113 shows antiglycating activity and inhibits advanced glycation end-product formation. α-Glucosidase-IN-113 can be used for the research of type 2 diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0089

*Acarbose* 5+ Cited Publications BAY g 5421	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Anti-aging Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-B0089R

Acarbose (Standard) BAY g 5421 (Standard)	Structural Classification Polysaccharides Microorganisms Saccharides Source Classification	Reference Standards Glycosidase
Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-B0089A

Acarbose sulfate Bay-g 5421 sulfate	Polysaccharides Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Acarbose (BAY g 5421) sulfate, antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC₅₀=11 nM). Acarbose sulfate can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-N17717

Vitexin-2''-O-glucoside Flavosativaside	Structural Classification Flavonoids Flavones Piper umbellatum L. Piperaceae Plants Source Classification	Glycosidase
Vitexin-2''-O-glucoside (Flavosativaside) is a potent and selective alpha-glucosidase inhibitor found in hawthorn leaf flavonoids. Vitexin-2''-O-glucoside can reversibly inhibit the α-glucosidase activity on the brush border of the small intestine, and its inhibitory effect is superior to that of the Acarbose (HY-B0089). Vitexin-2''-O-glucoside can be used for the research of type 2 diabetes .

Cat. No.	Product Name	Chemical Structure

HY-B0089S

Acarbose-d4
Acarbose-d₄ (BAY g 5421-d₄) is deuterium labeled Acarbose. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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acarbose

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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