3068686-30-3
Chemical Structure
α-Glucosidase-IN-79
- CAS No.: 3068686-30-3
- Formula:C21H22N2O5S
- Molecular Weight:414.47
InChIKey: VBDGGCCIXCGLDZ-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C#N)C(CCC(C)C2)=C2S1)COC3=C(OC)C(OC)=CC(C=O)=C3
Biological Activity: α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC50 of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (HY-B0089) (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes[1].
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α-Glucosidase-IN-79 | α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC50 of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (HY-B0089) (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes. | |||||||||||||||||||||
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Keywords
